Reference Libraries

October 1, 2020

Nell1 Protein Reduces the Number of Sunburned Cells and Modulates the Inflammatory Response after UV-induced Damage in a 3D Human Skin Model

NELL1 is a novel signaling protein that mediates tissue growth and maturation during fetal development and stimulates tissue healing post-injury in adult tissues. NELL1 promotes the production of a regenerative (fetal type) extracellular matrix (ECM) that provides the structural and... Read More

September 30, 2020

Nicotinamide Metabolism Modulates the Proliferation/Differentiation Balance and Senescence of Human Primary Keratinocytes

Nicotinamide (NAM) is the main precursor of nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for DNA repair, glycolysis, and oxidative phosphorylation. NAM has anti-aging activity on human skin, but the underlying mechanisms of action are unclear. Using 3-dimensional organotypic skin... Read More

September 24, 2020

Development of a chronic respiratory toxicity assay using an in vitro human airway model

Knowledge of chronic respiratory toxicity potential is important for establishing safe use of chemicals and consumer products. The current work describes efforts to develop an alternative, non-animal method for determining chronic (subacute) respiratory toxicity using the EpiAirway™ in vitro human... Read More

September 23, 2020

Evaluation of Phototoxic and Cytotoxic Potential of TiO2 Nanosheets in a 3D Reconstructed Human Skin Model

Despite a continuous increase in commercial products containing nanoparticles, only few materials are currently used in such large amounts, forms and sizes as titanium dioxide – TiO2. Besides their use in cosmetics, the food industry and biomedicine, TiO2 nanoparticles (NPs)... Read More