Reference Libraries

September 2, 2020

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

Cellular senescence has been shown to contribute to skin ageing. However, the role of melanocytes in the process is understudied. Our data show that melanocytes are the only epidermal cell type to express the senescence marker p16INK4A during human skin... Read More

September 2, 2020

Impact of Interleukin-6 on Drug-Metabolizing Enzymes and Transporters in Intestinal Cells

Inﬂammatory response is characterized by an increase of several cytokines. Some are known to modify drugs pharmacokinetic by reducing the expression levels of drug metabolizing enzymes (DMEs) and transporters. This impact of inﬂammatory signaling is well established in hepatic cells,... Read More

September 2, 2020

Reconstructed Human Epidermis Predicts Barrier-Improving Effects of Lactococcus lactis Emulsion in Humans

Background/Aims: The skin provides protection against chemical, physical, and biological stressors, yet the skin morphology changes over the course of life. These changes might affect the skin barrier function and facilitate the onset of age-related diseases. Since orally applied lactic... Read More

September 2, 2020

Assessment of Biological Responses of EpiAirway™ 3-D Cell Constructs vs. A549 Cells for Determining Toxicity of Ambient Air Pollution

Context — EpiAirway™ 3-D constructs are human-derived cell cultures of differentiated airway epithelial cells that may represent a more biologically relevant model of the human lung. However, limited information is available of its utility for exposures to air pollutants at... Read More

August 27, 2020

Dysregulated repair and inflammatory responses by e‐cigarette derived inhaled nicotine and humectant propylene glycol in a sex dependent manner in mouse lung

Nicotine inhalation via electronic cigarettes (e‐cigs) is an emerging concern. However, little is known about the acute toxicity in the lungs following inhalation of nicotine containing e‐cig aerosols. We hypothesized that acute exposure to aerosolized nicotine causes lung toxicity by... Read More

Reference Libraries

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

Impact of Interleukin-6 on Drug-Metabolizing Enzymes and Transporters in Intestinal Cells

Reconstructed Human Epidermis Predicts Barrier-Improving Effects of Lactococcus lactis Emulsion in Humans

Assessment of Biological Responses of EpiAirway™ 3-D Cell Constructs vs. A549 Cells for Determining Toxicity of Ambient Air Pollution

Dysregulated repair and inflammatory responses by e‐cigarette derived inhaled nicotine and humectant propylene glycol in a sex dependent manner in mouse lung

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