Reference Libraries

September 22, 2020

In-Depth Characterization of EpiIntestinal Microtissue as a Model for Intestinal Drug Absorption and Metabolism in Human

The Caco-2 model is a well-accepted in vitro model for the estimation of fraction absorbed in human intestine. Due to the lack of cytochrome P450 3A4 (CYP3A4) activities, Caco-2 model is not suitable for the investigation of intestinal first-pass metabolism.... Read More

September 22, 2020

In Search of Preventative Strategies: Novel Anti Inflammatory High-CBD Cannabis Sativa Extracts Modulate ACE2 Expression in COVID-19 Gateway Tissues

With the rapidly growing pandemic of COVID-19 caused by the new and challenging to treat zoonotic SARS-CoV2 coronavirus, there is an urgent need for new therapies and prevention strategies that can help curtail disease spread and reduce mortality. Inhibition of... Read More

September 22, 2020

Phenotypic Responses of Differentiated Asthmatic Human Airway Epithelial Cultures to Rhinovirus

Human airway epithelial cells are the principal target of human rhinovirus (HRV), a common cold pathogen that triggers the majority of asthma exacerbations. The objectives of this study were 1) to evaluate an invitro air liquid interface cultured human airway... Read More

September 21, 2020

In Vitro Demonstration of Intestinal Absorption Mechanisms of Different Sugars Using 3D Organotypic Tissues in a Fluidic Device

Intestinal permeability is crucial in regulating the bioavailability and, consequently, the biological effects of drugs and compounds. However, systematic and quantitative studies of the absorption of molecules are quite limited due to a lack of reliable experimental models able to... Read More

September 21, 2020

In vitro RHE skin sensitization assays: Applicability to challenging substances

In the last 20 years, alternative approaches to the identiﬁcation of skin sensitization hazards have been at the forefront of the 3Rs and have helped reﬁne the validation and acceptance processes. However, experience with the local lymph node assay showed... Read More

Reference Libraries

In-Depth Characterization of EpiIntestinal Microtissue as a Model for Intestinal Drug Absorption and Metabolism in Human

In Search of Preventative Strategies: Novel Anti Inflammatory High-CBD Cannabis Sativa Extracts Modulate ACE2 Expression in COVID-19 Gateway Tissues

Phenotypic Responses of Differentiated Asthmatic Human Airway Epithelial Cultures to Rhinovirus

In Vitro Demonstration of Intestinal Absorption Mechanisms of Different Sugars Using 3D Organotypic Tissues in a Fluidic Device

In vitro RHE skin sensitization assays: Applicability to challenging substances

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