Reference Libraries

August 12, 2019

Nintedanib-Cyclodextrin Complex to Improve Bio-Activity and Intestinal Permeability

Cyclodextrin complex of nintedanib was prepared aiming for increased bio-activity and improved transport across intestinal membrane with reduced p-glycoprotein (p-gp) efflux. Based on preliminary phase solubility studies and molecular modeling, sulfobutyl ether derivative of β-cyclodextrin (SBE-β-CD, Captisol®) was selected to... Read More

August 12, 2019

Toxicity of Food Contact Paper Evaluated by Combined Biological and Chemical Methods

The study was focused on assessment of potential health risks of paper-based food contact materials (FCMs) in a step-wise approach using three toxicological bioassays in vitro and chemical analyses of migrating contaminants. 3T3 NRU cytotoxicity test showed high sensitivity to... Read More

July 15, 2019

Measurement of Skin Pigmentation Using a Chromameter in a 3-Dimensional Epidermal Model Containing Functional Melanocytes

Cosmetic or skin care pharmaceutical formulations augment skin pigmentation either for the intended purpose of skin lightening or as an off-target effect. A convenient way to screen such effects utilizes the MelanoDerm tissue model, a highly differentiated, three-dimensional tissue culture... Read More

July 15, 2019

Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™)

Background: The rapid production and incorporation of engineered nanomaterials into consumer products alongside research suggesting nanomaterials can cause cell death and DNA damage (genotoxicity) makes in vitro assays desirable for nanosafety screening. However, conflicting outcomes are often observed when in... Read More

July 15, 2019

Standardization of In vitro Macrophotography for Assessment of Cutaneous Responses

The increased popularity of commercially available 3-dimensional human skin equivalents in recent years has allowed for assessment of melanogenesis modulated by compounds topically applied to the skin or directly incorporated from the medium. These skin equivalents provide a suitable model... Read More

Reference Libraries

Nintedanib-Cyclodextrin Complex to Improve Bio-Activity and Intestinal Permeability

Toxicity of Food Contact Paper Evaluated by Combined Biological and Chemical Methods

Measurement of Skin Pigmentation Using a Chromameter in a 3-Dimensional Epidermal Model Containing Functional Melanocytes

Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™)

Standardization of In vitro Macrophotography for Assessment of Cutaneous Responses

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