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April 2, 2019

Organotypic in vitro human airway models can recapitulate aspects of pulmonary fibrosis

Pulmonary fibrosis (PF) is a debilitating, typically fatal condition that may be caused by a variety of factors, including occupational and environmental exposures, drugs such as amiodarone and bleomycin, radiation exposure and genetic predisposition. However, in 20-30% of cases the... Read More

April 2, 2019

Toxicological comparison of cigarette smoke and e-cigarette aerosol using a 3D in vitro human respiratory model

Researchers recently performed a comparison test on cigarette smoke and e-cigarette aerosol on MatTek's EpiAirway in vitro human respiratory model.

January 25, 2019

In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures

Smoking has been associated with diseases of the lung and oral cavity. Here, we report our further assessment using EpiOral and EpiGingival.

January 25, 2019

Hyperosmolal vaginal lubricants markedly reduce epithelial barrier properties in a three-dimensional vaginal epithelium model

Hyperosmolal formulations are shown to cause toxicity to human colorectal epithelia in vivo, and increase vaginal transmission of genital herpes in the mouse/HSV model.

January 25, 2019

IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression

The intestinal epithelial barrier is maintained by expression of tight junctions that connect adjacent epithelial cells and seal the paracellular space.

Reference Libraries

Organotypic in vitro human airway models can recapitulate aspects of pulmonary fibrosis

Toxicological comparison of cigarette smoke and e-cigarette aerosol using a 3D in vitro human respiratory model

In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures

Hyperosmolal vaginal lubricants markedly reduce epithelial barrier properties in a three-dimensional vaginal epithelium model

IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression

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