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April 29, 2019

Hypoxia leads to abnormal epidermal differentiation via HIF-independent pathways

Atmospheric oxygen is important for the epidermis, as the skin epidermis is not greatly affected by blood circulation. Therefore, it is necessary to understand the effect of hypoxic signals on the epidermis as some environmental stimuli can induce skin hypoxia.... Read More

April 29, 2019

A Novel Assay for Evaluating Wound Healing in a Full-Thickness in vitro Human Skin Model

Wound healing is a fundamental process to re-establish tissue integrity and skin barrier function. A model of wound healing was created by introducing epidermal wounds in a full thickness in vitro human skin model (EpiDermFT) using a 3-mm punch biopsy... Read More

April 29, 2019

An In Vitro Versus In Vivo Toxicogenomic Investigation of Prenatal Exposures to Tobacco Smoke

Approximately 1 million women smoke during pregnancy despite evidence demonstrating serious juvenile and/ or adult diseases being linked to early-life exposure to cigarette smoke. Susceptibility could be determined by factors in previous generations, that is, prenatal or ‘‘maternal’’ exposures to... Read More

April 2, 2019

Assessment of Alveolar Toxicity and Fibrotic Potential In Vitro using the MatTek EpiAlveolar™ Model

In this study, EpiAlveolar™ from MatTek Corporation was examined to evaluate alveolar toxicity and the capacity of the model to assess fibrotic potential in vitro.

April 2, 2019

Organotypic in vitro human airway models can recapitulate aspects of pulmonary fibrosis

Pulmonary fibrosis (PF) is a debilitating, typically fatal condition that may be caused by a variety of factors, including occupational and environmental exposures, drugs such as amiodarone and bleomycin, radiation exposure and genetic predisposition. However, in 20-30% of cases the... Read More

Reference Libraries

Hypoxia leads to abnormal epidermal differentiation via HIF-independent pathways

A Novel Assay for Evaluating Wound Healing in a Full-Thickness in vitro Human Skin Model

An In Vitro Versus In Vivo Toxicogenomic Investigation of Prenatal Exposures to Tobacco Smoke

Assessment of Alveolar Toxicity and Fibrotic Potential In Vitro using the MatTek EpiAlveolar™ Model

Organotypic in vitro human airway models can recapitulate aspects of pulmonary fibrosis

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