Reference Libraries

August 17, 2016

Transcriptional profiling of radiation damage and preventive treatments in a 3-dimensional (3D) human cell culture model of oral mucositis

Cancer patients who receive radiation are often afflicted by oral mucositis, a debilitating disease, characterized by mouth sores and difficulty in swallowing. Oftentimes, cancer patients afflicted with mucositis must stop lifesaving therapies. Thus it is very important to prevent mucositis before it... Read More

August 17, 2016

Endo-glucanase digestion of oat β-Glucan enhances Dectin-1 activation in human dendritic cells

Oat β-Glucans were studied for their immunological impact before and after enzymatic digestion in order to enhance the efficacy of oat β-Glucans for application in functional foods. Oat β-Glucan is reported to have minimal impact compared to its fungal counterpart in vitro. Digestion... Read More

August 1, 2016

Antiviral Activity of Ribavirin, 2’,3’-Dideoxicitidine, Pirodavir, Oseltamivir and Infergen™ against RSV, Adeno-2, Rhino-14, Influenza and HCoV-EMC Infection in Differentiated Normal Bronchial Epithelial (dNHBE) Cells

The antiviral activity of ribavirin, 2’,3’-ddC, pirodavir, oseltamivir and Infergen™ was evaluated against respiratory syncytial virus (RSV), adenovirus type 2, rhinovirus type 14, influenza, and human coronavirus HCoV-EMC in a highly differentiated, three-dimensional, ex vivo model of normal human bronchial (dNHBE) cells.... Read More

July 26, 2016

Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

Systemic repeated dose safety assessment and systemic efficacy evaluation of substances are currently carried out on laboratory animals and in humans due to the lack of predictive alternatives. Relevant international regulations, such as OECD and ICH guidelines, demand long-term testing... Read More

December 11, 2015

β-GLUCOCEREBROSIDASE ACTIVITY IN MAMMALIAN STRATUM CORNEUM.

Although previous studies have demonstrated a crucial role for the enzyme â-glucocerebrosidase (GlcCer’ase) in the final steps of membrane structural maturation in mammalian stratum corneum (SC) and epidermal homeostasis, the precise in vivo localization of GlcCer’ase activity and protein is... Read More