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December 11, 2015

TOPICALLY APPLIED LACTIC ACID INCREASES SPONTANEOUS SECRETION OF VASCULAR ENDOTHELIAL GROWTH FACTOR BY HUMAN RECONSTRUCTED EPIDERMIS.

Background: Alpha-hydroxy acids (AHAs) are widely used for the treatment of hyperkeratotic skin disorders and photodamaged skin. Objectives: To investigate the effect of lactic acid (LA) on the secretion of cytokines by keratinocytes (KCs) of human reconstructed epidermis. Methods: Creams... Read More

December 11, 2015

ELUCIDATION OF XENOBIOTIC METABOLISM PATHWAYS IN HUMAN SKIN AND HUMAN SKIN MODELS BY PROTEOMIC PROFILING.

Background: Human skin has the capacity to metabolise foreign chemicals (xenobiotics), but knowledge of the various enzymes involved is incomplete. A broad-based unbiased proteomics approach was used to describe the profile of xenobiotic metabolising enzymes present in human skin and... Read More

December 11, 2015

FISETIN INHIBITS HUMAN MELANOMA CELL INVASION THROUGH PROMOTION OF MESENCHYMAL TO EPITHELIAL TRANSITION AND BY TARGETING MAPK AND NFкB SIGNALING PATHWAY.

Malignant melanoma is a serious form of cancer responsible for approximately 80% of skin cancer-related deaths. Activating mutations in the serine/threonine kinase BRAF occur in 60-70% of malignant melanomas. Preclinical studies have demonstrated that BRAF plays an important role in... Read More

December 11, 2015

RETENTION OF O-CYMEN-5-OL AND ZINC ON RECONSTRUCTED HUMAN GINGIVAL TISSUE FROM A TOOTHPASTE FORMULATION.

Objectives: To assess the retention of o-cymen-5-ol and zinc on reconstructed human gingival tissue delivered by topical applications of toothpaste formulated with 0.1%w⁄w o-cymen-5-ol and 0.6%w⁄w zinc chloride (ZnCl2). Methods: EpiGingivalTM tissues were treated topically for 2 minutes with either... Read More

December 11, 2015

β-GLUCOCEREBROSIDASE ACTIVITY IN MAMMALIAN STRATUM CORNEUM.

Although previous studies have demonstrated a crucial role for the enzyme â-glucocerebrosidase (GlcCer’ase) in the final steps of membrane structural maturation in mammalian stratum corneum (SC) and epidermal homeostasis, the precise in vivo localization of GlcCer’ase activity and protein is... Read More

Reference Libraries

TOPICALLY APPLIED LACTIC ACID INCREASES SPONTANEOUS SECRETION OF VASCULAR ENDOTHELIAL GROWTH FACTOR BY HUMAN RECONSTRUCTED EPIDERMIS.

ELUCIDATION OF XENOBIOTIC METABOLISM PATHWAYS IN HUMAN SKIN AND HUMAN SKIN MODELS BY PROTEOMIC PROFILING.

FISETIN INHIBITS HUMAN MELANOMA CELL INVASION THROUGH PROMOTION OF MESENCHYMAL TO EPITHELIAL TRANSITION AND BY TARGETING MAPK AND NFкB SIGNALING PATHWAY.

RETENTION OF O-CYMEN-5-OL AND ZINC ON RECONSTRUCTED HUMAN GINGIVAL TISSUE FROM A TOOTHPASTE FORMULATION.

β-GLUCOCEREBROSIDASE ACTIVITY IN MAMMALIAN STRATUM CORNEUM.

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