Reference Libraries

August 28, 2024

A Novel Meso-Scale MPS Integrated Organ Platform to Evaluate Usnic Acid Kinetics, Organ Distribution and Cytotoxicity: A Case Study

Background and Purpose: Usnic acid (UA) is a secondary metabolite obtained from lichens from the genus Usnea. UA has been reported to have a broad range of therapeutic uses that includes anti-inflammatory, antibacterial, and antiviral properties. In addition, UA is... Read More

August 28, 2024

Development of an in vitro Functional Assay to Evaluate the Occlusive Properties of Moisturizers on Dry Skin

Introduction: Dry skin is a hallmark of impaired skin barrier function. Moisturizers are a mainstay of treatment to help the skin retain moisture, and there is a high consumer demand for effective products. However, the development and optimization of new... Read More

August 28, 2024

Subcategorization of Eye Irritants Using the EpiOcular Time-to-Toxicity Test

As per OECD TG 405 “Acute Eye Irritation/ Corrosion”, albino rabbits were traditionally used to assess the eye damage/eye irritation of test materials. However, in 2015, OECD TG 492 “Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not... Read More

August 28, 2024

Reconstruction of novel 3D models of the three parts of small intestine for drug toxicity testing

Gastrointestinal (GI) toxicity is a common adverse event that limits pharmaceutical development across diverse therapy areas. The mechanisms of drug induced GI toxicity are often poorly understood, in part due to the lack of physiologically relevant in vitro models that... Read More

August 28, 2024

Toxicological Aspects of in vitro Oral Mucosa Wound Healing Models

Wounds in the oral cavity tissues can result from surgical procedures, accidents, and canker sores. Oral wounds present a site for potential infection and increased sensitivity to oral irritants. Untreated wounds can lead to pathogen invasion, chronic pain, poor cosmetic... Read More

Reference Libraries

A Novel Meso-Scale MPS Integrated Organ Platform to Evaluate Usnic Acid Kinetics, Organ Distribution and Cytotoxicity: A Case Study

Development of an in vitro Functional Assay to Evaluate the Occlusive Properties of Moisturizers on Dry Skin

Subcategorization of Eye Irritants Using the EpiOcular Time-to-Toxicity Test

Reconstruction of novel 3D models of the three parts of small intestine for drug toxicity testing

Toxicological Aspects of in vitro Oral Mucosa Wound Healing Models

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