Reference Libraries

December 11, 2015

NFAT REGULATES INDUCTION OF COX-2 AND APOPTOSIS OF KERATINOCYTES IN RESPONSE TO ULTRAVIOLET RADIATION EXPOSURE.

This study by researchers at Newcastle Univesity and the Royal Victoria Infirmary demonstrated that MatTek’s EpiDermFT full-thickness in vitro human skin tissue equivalent is an excellent in vitro model to investigate the wavelengths of UV radiation that activate specific skin... Read More

December 11, 2015

WOUND HEALING AND EXPRESSION OF ANTIMICROBIAL PEPTIDES/ POLYPEPTIDES IN HUMAN KERATINOCYTES, A CONSEQUENCE OF COMMON GROWTH FACTORS.

In addition to acting as a physical barrier against microorganisms, the skin produces antimicrobial peptides and proteins. After wounding, growth factors are produced to stimulate the regeneration of tissue. The growth factor response ceases after regeneration of the tissue, when... Read More

December 11, 2015

WOUNDING UPREGULATES VASCULAR ENDOTHELIAL GROWTH FACTOR PRODUCTION BY KERATINOCYTES OF IN VITRO RECONSTRUCTED HUMAN EPIDERMIS.

Vascular endothelial growth factor (VEGF) is produced by keratinocytes and has been implicated in the past in animal models as the major factor involved in wound healing associated angiogenesis. In the present study we investigated the effects of wounding on... Read More

December 11, 2015

IN VITRO EVALUATION OF AIRWAY TOXICITY USING THE EPIAIRWAY ORGANOTYPIC IN VITRO HUMAN AIRWAY MODEL.

Recent REACH legislation has heightened the need for validated in vitro airway toxicity models. However, in vitro determination of airway toxicity potential is problematic since submerged monolayer cell cultures are not amenable to dosing of vapors or water insoluble chemicals.... Read More

December 11, 2015

EVALUATION OF IN VITRO MODELS FOR REACH TOXICITY TESTING: INDUCIBILITY OF XENOBIOTIC METABOLIZING ENZYME (XME) ACTIVITY IN IN VITRO HUMAN AIRWAY (EPIAIRWAY™) AND EPIDERMAL (EPIDERM™) MODELS.

Dermal and airway epithelia contain XMEs including phase I (oxidative) and phase II (conjugative) activities. These XMEs may play a role in biotransformation of drugs and chemicals, leading to altered drug activity or formation of toxic/mutagenic metabolites. Consideration of metabolic... Read More

Reference Libraries

NFAT REGULATES INDUCTION OF COX-2 AND APOPTOSIS OF KERATINOCYTES IN RESPONSE TO ULTRAVIOLET RADIATION EXPOSURE.

WOUND HEALING AND EXPRESSION OF ANTIMICROBIAL PEPTIDES/ POLYPEPTIDES IN HUMAN KERATINOCYTES, A CONSEQUENCE OF COMMON GROWTH FACTORS.

WOUNDING UPREGULATES VASCULAR ENDOTHELIAL GROWTH FACTOR PRODUCTION BY KERATINOCYTES OF IN VITRO RECONSTRUCTED HUMAN EPIDERMIS.

IN VITRO EVALUATION OF AIRWAY TOXICITY USING THE EPIAIRWAY ORGANOTYPIC IN VITRO HUMAN AIRWAY MODEL.

EVALUATION OF IN VITRO MODELS FOR REACH TOXICITY TESTING: INDUCIBILITY OF XENOBIOTIC METABOLIZING ENZYME (XME) ACTIVITY IN IN VITRO HUMAN AIRWAY (EPIAIRWAY™) AND EPIDERMAL (EPIDERM™) MODELS.

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