Reference Libraries

December 11, 2015

NON-ANIMAL METHODS FOR TOXICITY TESTING: EMERGING RESEARCH, METHODS & POLICIES.

Areas of emerging skin research include: studies on skin regeneration and the mechanisms involved in skin irritation and wound healing; modifying existing in vitro methods to make them acceptable for a broader range of testing applications; and, development of new... Read More

December 11, 2015

AN IN VITRO HUMAN AIRWAY MODEL FOR RAPID TOXICITY AND FORMULATION SCREENING OF NASAL DRUG DELIVERY SYSTEMS.

INTRODUCTION: Purpose: Nasal delivery of protein and other high molecular weight drugs is an attractive option to injection or oral delivery. However, nasal drug delivery is limited by potential irritation/toxicity issues, difficulties in achieving effective doses and rapidity of clearance... Read More

December 11, 2015

IN VITRO AND IN VIVO SCREENING OF INTRANASAL INSULIN FORMULATIONS.

This study by researchers at Nastech Pharmaceuticals demonstrated that MatTek’s EpiAirway in vitro human tissue equivalents can be used by pharmaceutical companies to develop intranasal drug formulations that provide improved permeation in vivo of Active Pharmaceutical Ingredients (API’s). Nasal delivery... Read More

December 11, 2015

TOPICAL DELIVERY OF SIRNA-BASED SPHERICAL NUCLEIC ACID NANOPARTICLE CONJUGATES FOR GENE REGULATION

Topical application of nucleic acids offers many potential therapeutic advantages for suppressing genes in the skin, and potentially for systemic gene delivery. However, the epidermal barrier typically precludes entry of gene-suppressing therapy unless the barrier is disrupted. We now show... Read More

December 11, 2015

NON-ANIMAL APPROACHES FOR CONSUMER SAFETY RISK ASSESSMENTS: UNILEVER’S SCIENTIFIC RESEARCH PROGRAMME.

Non-animal based approaches to risk assessment are now routinely used for assuring consumer safety for some endpoints (such as skin irritation) following considerable investment in developing and applying new methods over the past 20 years. Unilever’s research programme into non-animal... Read More

Reference Libraries

NON-ANIMAL METHODS FOR TOXICITY TESTING: EMERGING RESEARCH, METHODS & POLICIES.

AN IN VITRO HUMAN AIRWAY MODEL FOR RAPID TOXICITY AND FORMULATION SCREENING OF NASAL DRUG DELIVERY SYSTEMS.

IN VITRO AND IN VIVO SCREENING OF INTRANASAL INSULIN FORMULATIONS.

TOPICAL DELIVERY OF SIRNA-BASED SPHERICAL NUCLEIC ACID NANOPARTICLE CONJUGATES FOR GENE REGULATION

NON-ANIMAL APPROACHES FOR CONSUMER SAFETY RISK ASSESSMENTS: UNILEVER’S SCIENTIFIC RESEARCH PROGRAMME.

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