Reference Libraries

December 11, 2015

THE ROLE OF MELANOMA TUMOR-DERIVED NITRIC OXIDE IN THE TUMOR INFLAMMATORY MICROENVIRONMENT: ITS IMPACT ON THE CHEMOKINE EXPRESSION PROFILE, INCLUDING SUPPRESSION OF CXCL10.

Melanoma appears to be heterogeneous in terms of its molecular biology, etiology and epidemiology. We previously reported that the expression of inducible nitric-oxide synthase (iNOS) in melanoma tumor cells is strongly correlated with poor patient survival. Therefore, we hypothesized that... Read More

December 11, 2015

IN VITRO APPROACHES FOR PREDICTING IRRITATION POTENTIAL OF TOPICAL EXPOSURES TO THE SKIN AND EYES.

Outline: Focus on topical exposure toxicity measures …Skin ……Corrosion ……Irritation –Chemicals ……Mildness –Formulations …Eye ……Physiology and modes of action –eye irritation ……Human Reconstructed Tissues ………Ingredients ………Mild formulation assessment …BCOP ……Moderate formulation assessment histology Conclusions: Skin Irritation/Corrosion …Validated methods are in... Read More

December 11, 2015

SULFUR MUSTARD TOXICITY FOLLOWING DERMAL EXPOSURE: ROLE OF OXIDATIVE STRESS, AND ANTIOXIDANT THERAPY.

Objective: Sulfur mustard (bis-2-(chloroethyl) sulfide) is a chemical warfare agent (military code: HD) causing extensive skin injury. The mechanisms underlying HD-induced skin damage are not fully elucidated. This review will critically evaluate the evidence showing that oxidative stress is an... Read More

December 11, 2015

IN VITRO AND IN VIVO SCREENING OF INTRANASAL INSULIN FORMULATIONS.

This study by researchers at Nastech Pharmaceuticals demonstrated that MatTek’s EpiAirway in vitro human tissue equivalents can be used by pharmaceutical companies to develop intranasal drug formulations that provide improved permeation in vivo of Active Pharmaceutical Ingredients (API’s). Nasal delivery... Read More

December 11, 2015

PREVENTION OF VAGINAL SHIV TRANSMISSION IN MACAQUES BY A LIVE RECOMBINANT LACTOBACILLUS.

Most human immunodeficiency virus (HIV) transmissions in women occur through the cervicovaginal mucosa, which is coated by a bacterial biofilm including Lactobacillus . This commensal bacterium has a role in maintaining a healthy mucosa and can be genetically engineered to... Read More

Reference Libraries

THE ROLE OF MELANOMA TUMOR-DERIVED NITRIC OXIDE IN THE TUMOR INFLAMMATORY MICROENVIRONMENT: ITS IMPACT ON THE CHEMOKINE EXPRESSION PROFILE, INCLUDING SUPPRESSION OF CXCL10.

IN VITRO APPROACHES FOR PREDICTING IRRITATION POTENTIAL OF TOPICAL EXPOSURES TO THE SKIN AND EYES.

SULFUR MUSTARD TOXICITY FOLLOWING DERMAL EXPOSURE: ROLE OF OXIDATIVE STRESS, AND ANTIOXIDANT THERAPY.

IN VITRO AND IN VIVO SCREENING OF INTRANASAL INSULIN FORMULATIONS.

PREVENTION OF VAGINAL SHIV TRANSMISSION IN MACAQUES BY A LIVE RECOMBINANT LACTOBACILLUS.

Get the latest