Reference Libraries

December 11, 2015

NON-ANIMAL APPROACHES FOR CONSUMER SAFETY RISK ASSESSMENTS: UNILEVER’S SCIENTIFIC RESEARCH PROGRAMME.

Non-animal based approaches to risk assessment are now routinely used for assuring consumer safety for some endpoints (such as skin irritation) following considerable investment in developing and applying new methods over the past 20 years. Unilever’s research programme into non-animal... Read More

December 11, 2015

AN IN VITRO HUMAN AIRWAY MODEL FOR RAPID TOXICITY AND FORMULATION SCREENING OF NASAL DRUG DELIVERY SYSTEMS.

INTRODUCTION: Purpose: Nasal delivery of protein and other high molecular weight drugs is an attractive option to injection or oral delivery. However, nasal drug delivery is limited by potential irritation/toxicity issues, difficulties in achieving effective doses and rapidity of clearance... Read More

December 11, 2015

ORGANOTYPIC IN VITRO HUMAN EPITHELIAL MODELS WITH ENGINEERED TOXICOLOGIC REPORTER FUNCTIONS.

3D organotypic in vitro human epithelial models including skin (e.g. EpiDerm, EpiDerm-FT) and airway (e.g. EpiAirway, EpiAirway-FT) are important advances over traditional monolayer cell culture models. For toxicology applications, these models provide more realistic, in vivo-like structure, barrier properties, metabolic... Read More

December 11, 2015

SULFUR MUSTARD TOXICITY FOLLOWING DERMAL EXPOSURE: ROLE OF OXIDATIVE STRESS, AND ANTIOXIDANT THERAPY.

Objective: Sulfur mustard (bis-2-(chloroethyl) sulfide) is a chemical warfare agent (military code: HD) causing extensive skin injury. The mechanisms underlying HD-induced skin damage are not fully elucidated. This review will critically evaluate the evidence showing that oxidative stress is an... Read More

December 11, 2015

EVALUATION OF IN VITRO MODELS FOR REACH TOXICITY TESTING: INDUCIBILITY OF XENOBIOTIC METABOLIZING ENZYME (XME) ACTIVITY IN IN VITRO HUMAN AIRWAY (EPIAIRWAY™) AND EPIDERMAL (EPIDERM™) MODELS.

Dermal and airway epithelia contain XMEs including phase I (oxidative) and phase II (conjugative) activities. These XMEs may play a role in biotransformation of drugs and chemicals, leading to altered drug activity or formation of toxic/mutagenic metabolites. Consideration of metabolic... Read More

Reference Libraries

NON-ANIMAL APPROACHES FOR CONSUMER SAFETY RISK ASSESSMENTS: UNILEVER’S SCIENTIFIC RESEARCH PROGRAMME.

AN IN VITRO HUMAN AIRWAY MODEL FOR RAPID TOXICITY AND FORMULATION SCREENING OF NASAL DRUG DELIVERY SYSTEMS.

ORGANOTYPIC IN VITRO HUMAN EPITHELIAL MODELS WITH ENGINEERED TOXICOLOGIC REPORTER FUNCTIONS.

SULFUR MUSTARD TOXICITY FOLLOWING DERMAL EXPOSURE: ROLE OF OXIDATIVE STRESS, AND ANTIOXIDANT THERAPY.

EVALUATION OF IN VITRO MODELS FOR REACH TOXICITY TESTING: INDUCIBILITY OF XENOBIOTIC METABOLIZING ENZYME (XME) ACTIVITY IN IN VITRO HUMAN AIRWAY (EPIAIRWAY™) AND EPIDERMAL (EPIDERM™) MODELS.

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