Reference Libraries

December 11, 2015

IN VITRO MODELS OF FULL-THICKNESS HUMAN SKIN (EPIDERMFT™) AND AIRWAY EPITHELIUM (EPIAIRWAYFT™) FOR TOXICOLOGY AND DRUG DEVELOPMENT APPLICATIONS.

In vitro models of human skin and airway epithelia have potential applications in toxicology studies involving chemical warfare agents, environmental chemicals or consumer products, as well as in development of therapeutics delivered via dermal or inhalation routes. However the response... Read More

December 11, 2015

AN IN VITRO HUMAN AIRWAY MODEL FOR RAPID TOXICITY AND FORMULATION SCREENING OF NASAL DRUG DELIVERY SYSTEMS.

INTRODUCTION: Purpose: Nasal delivery of protein and other high molecular weight drugs is an attractive option to injection or oral delivery. However, nasal drug delivery is limited by potential irritation/toxicity issues, difficulties in achieving effective doses and rapidity of clearance... Read More

December 11, 2015

FILTER-WELL TECHNOLOGY FOR ADVANCED THREE-DIMENSIONAL CELL CULTURE: PERSPECTIVES FOR RESPIRATORY RESEARCH.

Cell culture has long been a valuable tool for studying cell behaviour. Classical plastic substrates are two-dimensional, and usually promote cellular proliferation and inhibit differentiation. Understanding cell behaviour within complex multicellular tissues requires the systematic study of cells within the... Read More

December 11, 2015

SULFUR MUSTARD TOXICITY FOLLOWING DERMAL EXPOSURE: ROLE OF OXIDATIVE STRESS, AND ANTIOXIDANT THERAPY.

Objective: Sulfur mustard (bis-2-(chloroethyl) sulfide) is a chemical warfare agent (military code: HD) causing extensive skin injury. The mechanisms underlying HD-induced skin damage are not fully elucidated. This review will critically evaluate the evidence showing that oxidative stress is an... Read More

December 11, 2015

EVALUATION OF ANTI-INFLAMMATORY AND ATROPHOGENIC EFFECTS OF GLUCOCORTICOIDS ON RECONSTRUCTED HUMAN SKIN.

Topical glucocorticoids (GCs) are extensively used in the treatment of inflammatory skin diseases. However, their long-term use is often accompanied by severe and eventually irreversible adverse effects, with atrophy being the most important limitation. Currently, most non-clinical studies involve animal... Read More

Reference Libraries

IN VITRO MODELS OF FULL-THICKNESS HUMAN SKIN (EPIDERMFT™) AND AIRWAY EPITHELIUM (EPIAIRWAYFT™) FOR TOXICOLOGY AND DRUG DEVELOPMENT APPLICATIONS.

AN IN VITRO HUMAN AIRWAY MODEL FOR RAPID TOXICITY AND FORMULATION SCREENING OF NASAL DRUG DELIVERY SYSTEMS.

FILTER-WELL TECHNOLOGY FOR ADVANCED THREE-DIMENSIONAL CELL CULTURE: PERSPECTIVES FOR RESPIRATORY RESEARCH.

SULFUR MUSTARD TOXICITY FOLLOWING DERMAL EXPOSURE: ROLE OF OXIDATIVE STRESS, AND ANTIOXIDANT THERAPY.

EVALUATION OF ANTI-INFLAMMATORY AND ATROPHOGENIC EFFECTS OF GLUCOCORTICOIDS ON RECONSTRUCTED HUMAN SKIN.

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