Reference Libraries

December 11, 2015

PRECLINICAL EVALUATION OF LIME JUICE AS A TOPICAL MICROBICIDE CANDIDATE.

This study by researchers in the CONRAD (Contraceptive Research and Development) Program at Eastern Virginia Medical School and at St. George’s University/London demonstrated how MatTek’s EpiVaginal in vitro human cervico-vaginal tissue equivalent can be used pre-clinically to test potentially cytotoxic... Read More

December 11, 2015

IN VITRO EVALUATION OF AIRWAY TOXICITY USING THE EPIAIRWAY ORGANOTYPIC IN VITRO HUMAN AIRWAY MODEL.

Recent REACH legislation has heightened the need for validated in vitro airway toxicity models. However, in vitro determination of airway toxicity potential is problematic since submerged monolayer cell cultures are not amenable to dosing of vapors or water insoluble chemicals.... Read More

December 11, 2015

SULFUR MUSTARD TOXICITY FOLLOWING DERMAL EXPOSURE: ROLE OF OXIDATIVE STRESS, AND ANTIOXIDANT THERAPY.

Objective: Sulfur mustard (bis-2-(chloroethyl) sulfide) is a chemical warfare agent (military code: HD) causing extensive skin injury. The mechanisms underlying HD-induced skin damage are not fully elucidated. This review will critically evaluate the evidence showing that oxidative stress is an... Read More

December 11, 2015

EVALUATION OF IN VITRO MODELS FOR REACH TOXICITY TESTING: INDUCIBILITY OF XENOBIOTIC METABOLIZING ENZYME (XME) ACTIVITY IN IN VITRO HUMAN AIRWAY (EPIAIRWAY™) AND EPIDERMAL (EPIDERM™) MODELS.

Dermal and airway epithelia contain XMEs including phase I (oxidative) and phase II (conjugative) activities. These XMEs may play a role in biotransformation of drugs and chemicals, leading to altered drug activity or formation of toxic/mutagenic metabolites. Consideration of metabolic... Read More

December 11, 2015

RECONSTITUTED 3-DIMENSIONAL HUMAN SKIN OF VARIOUS ETHNIC ORIGINS AS AN IN VITRO MODEL FOR STUDIES OF PIGMENTATION.

Reconstituted 3-dimensional human skin equivalents containing melanocytes and keratinocytes on an artifcial dermal substitute are gaining popularity for studies of skin metabolism because they exhibit morphological and growth characteristics similar to human epidermis. In this study, we show that such... Read More

Reference Libraries

PRECLINICAL EVALUATION OF LIME JUICE AS A TOPICAL MICROBICIDE CANDIDATE.

IN VITRO EVALUATION OF AIRWAY TOXICITY USING THE EPIAIRWAY ORGANOTYPIC IN VITRO HUMAN AIRWAY MODEL.

SULFUR MUSTARD TOXICITY FOLLOWING DERMAL EXPOSURE: ROLE OF OXIDATIVE STRESS, AND ANTIOXIDANT THERAPY.

EVALUATION OF IN VITRO MODELS FOR REACH TOXICITY TESTING: INDUCIBILITY OF XENOBIOTIC METABOLIZING ENZYME (XME) ACTIVITY IN IN VITRO HUMAN AIRWAY (EPIAIRWAY™) AND EPIDERMAL (EPIDERM™) MODELS.

RECONSTITUTED 3-DIMENSIONAL HUMAN SKIN OF VARIOUS ETHNIC ORIGINS AS AN IN VITRO MODEL FOR STUDIES OF PIGMENTATION.

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