Reference Libraries

December 11, 2015

SULFUR MUSTARD TOXICITY FOLLOWING DERMAL EXPOSURE: ROLE OF OXIDATIVE STRESS, AND ANTIOXIDANT THERAPY.

Objective: Sulfur mustard (bis-2-(chloroethyl) sulfide) is a chemical warfare agent (military code: HD) causing extensive skin injury. The mechanisms underlying HD-induced skin damage are not fully elucidated. This review will critically evaluate the evidence showing that oxidative stress is an... Read More

December 11, 2015

IN VITRO EVALUATION OF AIRWAY TOXICITY USING THE EPIAIRWAY ORGANOTYPIC IN VITRO HUMAN AIRWAY MODEL.

Recent REACH legislation has heightened the need for validated in vitro airway toxicity models. However, in vitro determination of airway toxicity potential is problematic since submerged monolayer cell cultures are not amenable to dosing of vapors or water insoluble chemicals.... Read More

December 11, 2015

THE ROLE OF MELANOMA TUMOR-DERIVED NITRIC OXIDE IN THE TUMOR INFLAMMATORY MICROENVIRONMENT: ITS IMPACT ON THE CHEMOKINE EXPRESSION PROFILE, INCLUDING SUPPRESSION OF CXCL10.

Melanoma appears to be heterogeneous in terms of its molecular biology, etiology and epidemiology. We previously reported that the expression of inducible nitric-oxide synthase (iNOS) in melanoma tumor cells is strongly correlated with poor patient survival. Therefore, we hypothesized that... Read More

December 11, 2015

MELANODERM™: AN EPIDERMAL TISSUE MODEL CONTAINING FUNCTIONAL MELANOCYTES.

Organotypic skin models provide a useful, non-animal method of assessing the irritancy and efficacy properties of various cosmetic products. To address the modulation of skin pigmentation, MatTek Corporation has developed MelanoDerm™, a highly differentiated, three-dimensional tissue culture model of human... Read More

December 11, 2015

FORSKOLIN PROTECTS KERATINOCYTES FROM UVB-INDUCED APOPTOSIS AND INCREASES DNA REPAIR INDEPENDENT OF ITS EFFECTS ON MELANOGENESIS.

This study by researchers in the Laboratory of Cell Biology, National Cancer Institute (National Institutes of Health) demonstrated that MatTek’s melanocyte/keratinocyte-containing MelanoDerm in vitro human skin tissue equivalent can be used to investigate the ability of a topically applied compound... Read More

Reference Libraries

SULFUR MUSTARD TOXICITY FOLLOWING DERMAL EXPOSURE: ROLE OF OXIDATIVE STRESS, AND ANTIOXIDANT THERAPY.

IN VITRO EVALUATION OF AIRWAY TOXICITY USING THE EPIAIRWAY ORGANOTYPIC IN VITRO HUMAN AIRWAY MODEL.

THE ROLE OF MELANOMA TUMOR-DERIVED NITRIC OXIDE IN THE TUMOR INFLAMMATORY MICROENVIRONMENT: ITS IMPACT ON THE CHEMOKINE EXPRESSION PROFILE, INCLUDING SUPPRESSION OF CXCL10.

MELANODERM™: AN EPIDERMAL TISSUE MODEL CONTAINING FUNCTIONAL MELANOCYTES.

FORSKOLIN PROTECTS KERATINOCYTES FROM UVB-INDUCED APOPTOSIS AND INCREASES DNA REPAIR INDEPENDENT OF ITS EFFECTS ON MELANOGENESIS.

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