Reference Libraries

December 11, 2015

HUMAN SKIN RESPONSES TO UV RADIATION: PIGMENT IN THE UPPER EPIDERMIS PROTECTS AGAINST DNA DAMAGE IN THE LOWER EPIDERMIS AND FACILITATES APOPTOSIS.

This study by researchers at the National Cancer Institute and the US Food and Drug Administration demonstrated how MatTek’s MelanoDerm reconstructed 3-D in vitro human skin tissues containing both keratinocytes and melanocytes could be used to investigate how increased melanin... Read More

December 11, 2015

SOX9 IS A KEY PLAYER IN ULTRAVIOLET B-INDUCED MELANOCYTE DIFFERENTIATION AND PIGMENTATION.

This study by researchers from the National Cancer Institute (USA) and the Universite de Nice Sophia–Antipolis (France) demonstrated the ability to use MelanoDerm, one of MatTek’s re-constructed skin models, as a surrogate to assess the effect of UVB radiation on... Read More

December 11, 2015

IN VITRO EXPOSURE OF ORGANOTYPICAL 3D EPITHELIAL TISSUES TO CIGARETTE SMOKE AS A POTENTIAL ALTERNATIVE TO RODENT INHALATION STUDIES.

Airway epithelium is the initial barrier affected by toxic gases or particles in the atmosphere, such as cigarette smoke (CS), which induces, among other things, inflammatory processes that can lead to COPD and tissue remodeling (Takizawa 2001, Yoshida 2007). Here... Read More

December 11, 2015

DEVELOPMENT OF AN EPIORAL IN VITRO HUMAN TISSUE MODEL FOR ORAL IRRITANCY TESTING.

This study by researchers at British American Tobacco and Advanced Technologies Ltd. demonstrated that MatTek’s EpiOral in vitro human buccal (inner cheek) tissue equivalent is an excellent in vitro model for analyzing the human oral irritation potential of tobacco products.... Read More

December 11, 2015

GENOMIC BIOMARKERS OF PULMONARY EXPOSURE TO TOBACCO SMOKE COMPONENTS.

This study by researchers at the Cardiff University School of Biosciences demonstrated that MatTek’s EpiAirway in vitro human tracheal/bronchial tissue equivalent can be used to accurately model the genetic effects of tobacco smoke component exposure on human respiratory epithelium. Background:... Read More

Reference Libraries

HUMAN SKIN RESPONSES TO UV RADIATION: PIGMENT IN THE UPPER EPIDERMIS PROTECTS AGAINST DNA DAMAGE IN THE LOWER EPIDERMIS AND FACILITATES APOPTOSIS.

SOX9 IS A KEY PLAYER IN ULTRAVIOLET B-INDUCED MELANOCYTE DIFFERENTIATION AND PIGMENTATION.

IN VITRO EXPOSURE OF ORGANOTYPICAL 3D EPITHELIAL TISSUES TO CIGARETTE SMOKE AS A POTENTIAL ALTERNATIVE TO RODENT INHALATION STUDIES.

DEVELOPMENT OF AN EPIORAL IN VITRO HUMAN TISSUE MODEL FOR ORAL IRRITANCY TESTING.

GENOMIC BIOMARKERS OF PULMONARY EXPOSURE TO TOBACCO SMOKE COMPONENTS.

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