Reference Libraries

December 11, 2015

PRECLINICAL EVALUATION OF LIME JUICE AS A TOPICAL MICROBICIDE CANDIDATE.

This study by researchers in the CONRAD (Contraceptive Research and Development) Program at Eastern Virginia Medical School and at St. George’s University/London demonstrated how MatTek’s EpiVaginal in vitro human cervico-vaginal tissue equivalent can be used pre-clinically to test potentially cytotoxic... Read More

December 11, 2015

IN VITRO EVALUATION OF AIRWAY TOXICITY USING THE EPIAIRWAY ORGANOTYPIC IN VITRO HUMAN AIRWAY MODEL.

Recent REACH legislation has heightened the need for validated in vitro airway toxicity models. However, in vitro determination of airway toxicity potential is problematic since submerged monolayer cell cultures are not amenable to dosing of vapors or water insoluble chemicals.... Read More

December 11, 2015

THE INCLUSION COMPLEX OF 4-HYDROXYNONENAL WITH A POLYMERIC DERIVATIVE OF Β-CYCLODEXTRIN ENHANCES THE ANTITUMORAL EFFICACY OF THE ALDEHYDE IN SEVERAL TUMOR CELL LINES AND IN A THREE-DIMENSIONAL HUMAN MELANOMA MODEL.

4-Hydroxynonenal (HNE) is the most studied end product of the lipoperoxidation process, by virtue of its relevant biological activity. The antiproliferative and proapoptotic effects of HNE have been widely demonstrated in a great variety of tumor cell types in vitro.... Read More

December 11, 2015

NON-ANIMAL APPROACHES FOR CONSUMER SAFETY RISK ASSESSMENTS: UNILEVER’S SCIENTIFIC RESEARCH PROGRAMME.

Non-animal based approaches to risk assessment are now routinely used for assuring consumer safety for some endpoints (such as skin irritation) following considerable investment in developing and applying new methods over the past 20 years. Unilever’s research programme into non-animal... Read More

December 11, 2015

THE ROLE OF MELANOMA TUMOR-DERIVED NITRIC OXIDE IN THE TUMOR INFLAMMATORY MICROENVIRONMENT: ITS IMPACT ON THE CHEMOKINE EXPRESSION PROFILE, INCLUDING SUPPRESSION OF CXCL10.

Melanoma appears to be heterogeneous in terms of its molecular biology, etiology and epidemiology. We previously reported that the expression of inducible nitric-oxide synthase (iNOS) in melanoma tumor cells is strongly correlated with poor patient survival. Therefore, we hypothesized that... Read More

Reference Libraries

PRECLINICAL EVALUATION OF LIME JUICE AS A TOPICAL MICROBICIDE CANDIDATE.

IN VITRO EVALUATION OF AIRWAY TOXICITY USING THE EPIAIRWAY ORGANOTYPIC IN VITRO HUMAN AIRWAY MODEL.

THE INCLUSION COMPLEX OF 4-HYDROXYNONENAL WITH A POLYMERIC DERIVATIVE OF Β-CYCLODEXTRIN ENHANCES THE ANTITUMORAL EFFICACY OF THE ALDEHYDE IN SEVERAL TUMOR CELL LINES AND IN A THREE-DIMENSIONAL HUMAN MELANOMA MODEL.

NON-ANIMAL APPROACHES FOR CONSUMER SAFETY RISK ASSESSMENTS: UNILEVER’S SCIENTIFIC RESEARCH PROGRAMME.

THE ROLE OF MELANOMA TUMOR-DERIVED NITRIC OXIDE IN THE TUMOR INFLAMMATORY MICROENVIRONMENT: ITS IMPACT ON THE CHEMOKINE EXPRESSION PROFILE, INCLUDING SUPPRESSION OF CXCL10.

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