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December 11, 2015

IMPROVEMENTS TO MELANODERM™, AN EPIDERMAL MODEL CONTAINING FUNCTIONAL MELANOCYTES FOR SKIN LIGHTENING STUDIES.

Clinical skin lightening studies often run in excess of 3 months duration and are very costly. Therefore, there is considerable interest in developing methodology using cultured skin tissues to perform such studies in vitro. Towards this end, we have produced... Read More

December 11, 2015

RESULTS USING MELANODERM™, AN EPIDERMAL MODEL CONTAINING FUNCTIONAL MELANOCYTES, DEMONSTRATE EFFICACY OF NOVEL SKIN LIGHTENING FORMULATIONS.

To minimize the cost of human clinical studies and shorten the time to market, we have used the MelanoDerm skin model (MatTek Corporation) to screen novel skin lightening formulations that we have recently developed. The formulations were applied topically to... Read More

December 11, 2015

A LOTION CONTAINING UNDECYLENOYL PHENYLALANINE AND ERGOTHIONEINE REDUCES MELANIN LEVELS WITHOUT AFFECTING TISSUE VIABILITY IN ARTIFICIAL SKIN CONSTRUCTS.

This study by scientists at AGI Dermatics demonstrated that MatTek’s MelanoDerm in vitro human skin tissue equivalent can be used to evaluate the depigmentation (lightening) effects of skin lotion additives caused by a reduction in melanin production without tissue/cell toxicity.... Read More

December 11, 2015

A ZN(LL)-GLYCINE COMPLEX SUPPRESSES UVB-INDUCED MELANIN PRODUCTION BY STIMULATING METALLOTHIONEIN EXPRESSION.

Oxidative stress caused by ultraviolet (UV) radiation generates reactive oxygen species (ROS) in the skin, induces the secretion of melanocyte growth and activating factors from keratinocytes, which results in the formation of cutaneous hyperpigmentation. Thus, increasing the anti-oxidative ability of... Read More

December 11, 2015

SUPPRESSED PERMEATION OF LINOLEIC ACID IN A LIPOSOMAL FORMULATION THROUGH RECONSTRUCTED SKIN TISSUE.

This study by researchers at Okayama University Graduate School of Natural Science and Technology, SUNSTAR, Inc., and the University of Shizuoka School of Pharmaceutical Sciences demonstrated that MatTek’s MelanoDerm in vitro human skin tissue equivalent is an excellent in vitro... Read More

Reference Libraries

IMPROVEMENTS TO MELANODERM™, AN EPIDERMAL MODEL CONTAINING FUNCTIONAL MELANOCYTES FOR SKIN LIGHTENING STUDIES.

RESULTS USING MELANODERM™, AN EPIDERMAL MODEL CONTAINING FUNCTIONAL MELANOCYTES, DEMONSTRATE EFFICACY OF NOVEL SKIN LIGHTENING FORMULATIONS.

A LOTION CONTAINING UNDECYLENOYL PHENYLALANINE AND ERGOTHIONEINE REDUCES MELANIN LEVELS WITHOUT AFFECTING TISSUE VIABILITY IN ARTIFICIAL SKIN CONSTRUCTS.

A ZN(LL)-GLYCINE COMPLEX SUPPRESSES UVB-INDUCED MELANIN PRODUCTION BY STIMULATING METALLOTHIONEIN EXPRESSION.

SUPPRESSED PERMEATION OF LINOLEIC ACID IN A LIPOSOMAL FORMULATION THROUGH RECONSTRUCTED SKIN TISSUE.

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