Reference Libraries

Organotypic skin models provide a useful, non-animal means to assess the irritancy and efficacy properties of various cosmetic products. To address the modulation of skin pigmentation, MatTek Corporation has developed MelanoDerm, a highly differentiated, three-dimensional tissue culture model of human... Read More

The protease-activated receptor 2, expressed on keratinocytes but not on melanocytes, has been ascribed functional importance in the regulation of pigmentation by phagocytosis of melanosomes. Inhibition of protease-activated receptor 2 activation by synthetic serine protease inhibitors requires keratinocyte-melanocyte contact and... Read More

Tyrosinase has long been commonly considered as the sole enzyme involved in melanogenesis and has served as target to develop whitening agents. But, over the past decade, it has become well accepted that melanins pathways involve many other enzymes such... Read More

This study by researchers at Toyo Beauty Co., Ltd., Jichi Medical University, and Kinki University (Japan) demonstrated how MatTek’s MelanoDerm 3-D human skin tissue equivalent containing both keratinocytes and melanocytes can be used as an in vitro test of the... Read More

To minimize the cost of human clinical studies and shorten the time to market, we have used the MelanoDerm skin model (MatTek Corporation) to screen novel skin lightening formulations that we have recently developed. The formulations were applied topically to... Read More