Reference Libraries

This study by researchers at Toyo Beauty Co., Ltd., Jichi Medical University, and Kinki University (Japan) demonstrated how MatTek’s MelanoDerm 3-D human skin tissue equivalent containing both keratinocytes and melanocytes can be used as an in vitro test of the... Read More

Tyrosinase has long been commonly considered as the sole enzyme involved in melanogenesis and has served as target to develop whitening agents. But, over the past decade, it has become well accepted that melanins pathways involve many other enzymes such... Read More

The protease-activated receptor 2, expressed on keratinocytes but not on melanocytes, has been ascribed functional importance in the regulation of pigmentation by phagocytosis of melanosomes. Inhibition of protease-activated receptor 2 activation by synthetic serine protease inhibitors requires keratinocyte-melanocyte contact and... Read More

Close association exists between melanocytes, the pigment melanin-producing cells in the body, and their neighboring keratinocytes. Keratinocytes are the pigment recipients and skin pigmentation is the result of this interaction. While the chemical basis of melanin production (melanogenesis) is well... Read More