Reference Libraries

Many different biological pathways have been implicated in the control of pigmentation including various signal transduction pathways and the cell cycle. We have analyzed key proteins in these pathways in normal human epidermal melanocytes including PKCbI, PKCbII, ERKI,2, MEK, pRb,... Read More

There is considerable interest in developing both cosmetic and pharma-ceutical formulations which cause darkening or lightening of the skin. These products are utilized to cosmetically alter one’s natural skin color, to provide natural protection from UV irradiation (by increasing melanin... Read More

Melanin in the epidermis determines the wide variation in skin color associated with ethnic skin diversity. Ethnic differences exist regarding melanosome loss in keratinocytes, but the mechanisms underlying these differences, and their contribution to the regulation of skin color, remain... Read More