Reference Libraries

Close association exists between melanocytes, the pigment melanin-producing cells in the body, and their neighboring keratinocytes. Keratinocytes are the pigment recipients and skin pigmentation is the result of this interaction. While the chemical basis of melanin production (melanogenesis) is well... Read More

The protease-activated receptor 2, expressed on keratinocytes but not on melanocytes, has been ascribed functional importance in the regulation of pigmentation by phagocytosis of melanosomes. Inhibition of protease-activated receptor 2 activation by synthetic serine protease inhibitors requires keratinocyte-melanocyte contact and... Read More

Organotypic skin models provide a useful, non-animal means to assess the irritancy and efficacy properties of various cosmetic products. To address the modulation of skin pigmentation, MatTek Corporation has developed MelanoDerm, a highly differentiated, three-dimensional tissue culture model of human... Read More