Reference Libraries

There is considerable interest in developing both cosmetic and pharma-ceutical formulations which cause darkening or lightening of the skin. These products are utilized to cosmetically alter one’s natural skin color, to provide natural protection from UV irradiation (by increasing melanin... Read More

This study by researchers at Nippon Medical School and Tokai University School of Medicine in Japan demonstrated that MatTek’s MelanoDerm in vitro human skin tissue equivalent can be used to demonstrate that a compound (quercetin) has an effect on the... Read More

The chemical basis of melanogenesis is well documented, but the mechanism of melanosome transfer and the regulation of pigmentation by keratinocyte-melanocyte interactions are not well understood. Therefore we examined the effects of serine protease inhibitors on skin pigmentation and found... Read More

Many different biological pathways have been implicated in the control of pigmentation including various signal transduction pathways and the cell cycle. We have analyzed key proteins in these pathways in normal human epidermal melanocytes including PKCbI, PKCbII, ERKI,2, MEK, pRb,... Read More