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December 11, 2015

MELANODERM, AN EPIDERMAL TISSUE TO EVALUATE SKIN LIGHTENING AND DARKENING.

There is considerable interest in developing new cosmetic and skin care pharmaceutical formulations which modulate pigmentation of the skin. These products will be utilized to cosmetically alter one’s natural skin color (artificial tanning or skin lightening) or to combat skin... Read More

December 11, 2015

A ZN(LL)-GLYCINE COMPLEX SUPPRESSES UVB-INDUCED MELANIN PRODUCTION BY STIMULATING METALLOTHIONEIN EXPRESSION.

Oxidative stress caused by ultraviolet (UV) radiation generates reactive oxygen species (ROS) in the skin, induces the secretion of melanocyte growth and activating factors from keratinocytes, which results in the formation of cutaneous hyperpigmentation. Thus, increasing the anti-oxidative ability of... Read More

December 11, 2015

DICKKOPF 1 (DKK1) REGULATES SKIN PIGMENTATION AND THICKNESS BY AFFECTING WNT/â-CATENIN SIGNALING IN KERATINOCYTES.

This study by researchers at the National Cancer Institute (USA), Osaka University Graduate School of Medicine (Japan) and Nagoya City University Graduate School of Medical Sciences (Japan) demonstrated the ability to reproduce the expression patterns of key proteins observed in... Read More

December 11, 2015

COMPARISON OF FUNCTIONAL PIGMENTATION ASSAYS.

Many different biological pathways have been implicated in the control of pigmentation including various signal transduction pathways and the cell cycle. We have analyzed key proteins in these pathways in normal human epidermal melanocytes including PKCbI, PKCbII, ERKI,2, MEK, pRb,... Read More

December 11, 2015

IDENTIFICATION OF QUINOLINES THAT INHIBIT MELANOGENESIS BY ALTERING TYROSINASE FAMILY TRAFFICKING.

This study by scientists at the New York University School of Medicine and PTC Therapeutics demonstrated how MatTek’s MelanoDerm in vitro human skin tissue equivalent can be used to measure the depigmenting effects of human skin lightening agents. A series... Read More

Reference Libraries

MELANODERM, AN EPIDERMAL TISSUE TO EVALUATE SKIN LIGHTENING AND DARKENING.

A ZN(LL)-GLYCINE COMPLEX SUPPRESSES UVB-INDUCED MELANIN PRODUCTION BY STIMULATING METALLOTHIONEIN EXPRESSION.

DICKKOPF 1 (DKK1) REGULATES SKIN PIGMENTATION AND THICKNESS BY AFFECTING WNT/â-CATENIN SIGNALING IN KERATINOCYTES.

COMPARISON OF FUNCTIONAL PIGMENTATION ASSAYS.

IDENTIFICATION OF QUINOLINES THAT INHIBIT MELANOGENESIS BY ALTERING TYROSINASE FAMILY TRAFFICKING.

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