December 11, 2015
RECONSTRUCTED HUMAN EPIDERMIS EQUIVALENTS.
Special Section. (See MatTek TR’s 276 thru 283.)
Reference Libraries
December 11, 2015
UPDATE ON VALIDATION STATUS AND INDUSTRY UTILIZATION OF NORMAL HUMAN 3D (NHU-3D) ANIMAL ALTERNATIVE MODELS.
Progress in in vitro tissue engineering over the last several decades has contributed to a significant decrease in animal use for industrial risk and safety assessment of products and ingredients. MatTek Corporation has a long-standing involvement in development, production and... Read More
December 11, 2015
PRESENCE OF HYDROCORTISONE DRAMATICALLY AFFECTS CYTOKINE PRODUCTION FOLLOWING UV IRRADIATION IN 3-DIMENSIONAL SKIN MODEL EPIDERM.
Dating back to work originally done by Rheinwald and Green, hydrocortisone (HC) is commonly used in culture media for epithelial cells, especially keratinocytes. In the culture of EpiDerm™, a highly differentiated, three-dimensional model of the human epidermis, this additive is... Read More
December 11, 2015
AN IN VITRO METHOD FOR SCREENING SKIN-WHITENING PRODUCTS.
Melanoderm™ (MatTek) is an in vitro model of the human epidermis consisting of well-differentiated, cultured human keratinocytes and melanocytes. We utilized this model to evaluate the efficacy, stability, and cytotoxicity of whitening agents. Magnesium ascorbyl phosphate (MAP), kojic acid and... Read More
December 11, 2015
INITIAL IN VITRO SCREENING APPROACH TO INVESTIGATE THE POTENTIAL HEALTH AND ENVIRONMENTAL HAZARDS OF ENVIROX™ – A NANOPARTICULATE CERIUM OXIDE DIESEL FUEL ADDITIVE.
This study by scientists at Oxonica, Product Assessment & Regulatory Compliance, and SafePharm Laboratories Ltd. demonstrated that MatTek’s EpiDerm in vitro tissue model system can be used to determine the skin irritation potential of formulations containing nanoparticles. Nanotechnology is the... Read More
