Reference Libraries

Background: Skin-lightening preparations are used by people all over the world for a diverse range of dermatologic indications. The gold standard treatment for skin lightening is with hydroquinone but has been controversial because of the presence of several side effects.... Read More

We studied the inhibitory effects of 4-hydroxyphenyl á-glucopyranoside (á-arbutin) on melanogenesis in cultured human melanoma cells, HMV-II, and in a three-dimensional cultured human skin model. á-Arbutin showed no inhibitory effect on HMV-II cell growth at a concentration below 1.0 mM.... Read More

Screening for tyrosinase (TYR) inhibitors potentially useful for control of skin pigmentation has been hampered by the limited availability of human TYR. To overcome this hurdle, we have established human embryonic kidney (HEK293)-TYR cells that constitutively express human TYR. In... Read More