Reference Libraries

Organotypic skin models provide a useful, non-animal means to assess the irritancy and efficacy properties of various cosmetic products. To address the modulation of skin pigmentation, MatTek Corporation has developed MelanoDerm, a highly differentiated, three-dimensional tissue culture model of human... Read More

This study by scientists at AGI Dermatics demonstrated that MatTek’s MelanoDerm in vitro human skin tissue equivalent can be used to evaluate the depigmentation (lightening) effects of skin lotion additives caused by a reduction in melanin production without tissue/cell toxicity.... Read More

There is substantial interest in evaluating cosmetic raw materials for effects on melanin production. Since tyrosinase activity is considered rate limiting in melanogenesis, potential skin lightening materials are often screened by measuring their effects on this enzyme. However, melanogenesis involves... Read More