Reference Libraries

December 11, 2015

PRESENCE OF HYDROCORTISONE DRAMATICALLY AFFECTS CYTOKINE PRODUCTION FOLLOWING UV IRRADIATION IN 3-DIMENSIONAL SKIN MODEL EPIDERM.

Dating back to work originally done by Rheinwald and Green, hydrocortisone (HC) is commonly used in culture media for epithelial cells, especially keratinocytes. In the culture of EpiDerm™, a highly differentiated, three-dimensional model of the human epidermis, this additive is... Read More

December 11, 2015

INHIBITORY EFFECTS OF Á-ARBUTIN ON MELANIN SYNTHESIS IN CULTURED HUMAN MELANOMA CELLS AND A THREE-DIMENSIONAL HUMAN SKIN MODEL.

We studied the inhibitory effects of 4-hydroxyphenyl á-glucopyranoside (á-arbutin) on melanogenesis in cultured human melanoma cells, HMV-II, and in a three-dimensional cultured human skin model. á-Arbutin showed no inhibitory effect on HMV-II cell growth at a concentration below 1.0 mM.... Read More

December 11, 2015

FORMULATION OPTIMIZATION, SKIN IRRITATION, AND EFFICACY CHARACTERIZATION OF A NOVEL SKIN-LIGHTENING AGENT.

Background: Skin-lightening preparations are used by people all over the world for a diverse range of dermatologic indications. The gold standard treatment for skin lightening is with hydroquinone but has been controversial because of the presence of several side effects.... Read More

December 11, 2015

Skin irritation and potential efficacy of a novel compound for localized treatment of psoriasis

Psoriasis is a chronic condition characterized by formation of white scaly patches on the skin. Current treatment options include topical glucocorticoids which have several side effects. Pentaerythritol tetrakis (3,5-di-tert-butyl-4-hydroxyhydrocinnamate) (PTTC) is a cinnamate tetraester which may be used as a... Read More

December 11, 2015

NON-ANIMAL METHODS FOR TOXICITY TESTING: SKIN IRRITATION/CORROSION.

Skin toxicity refers to the local toxic effects resulting from a topical exposure of the skin to a substance. Skin toxicities include skin irritation and skin corrosion. The Globally Harmonized System of Classification and Labeling of Chemicals (GHS) defines skin... Read More

Reference Libraries

PRESENCE OF HYDROCORTISONE DRAMATICALLY AFFECTS CYTOKINE PRODUCTION FOLLOWING UV IRRADIATION IN 3-DIMENSIONAL SKIN MODEL EPIDERM.

INHIBITORY EFFECTS OF Á-ARBUTIN ON MELANIN SYNTHESIS IN CULTURED HUMAN MELANOMA CELLS AND A THREE-DIMENSIONAL HUMAN SKIN MODEL.

FORMULATION OPTIMIZATION, SKIN IRRITATION, AND EFFICACY CHARACTERIZATION OF A NOVEL SKIN-LIGHTENING AGENT.

Skin irritation and potential efficacy of a novel compound for localized treatment of psoriasis

NON-ANIMAL METHODS FOR TOXICITY TESTING: SKIN IRRITATION/CORROSION.

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