December 11, 2015
RECONSTRUCTED HUMAN EPIDERMIS EQUIVALENTS.
Special Section. (See MatTek TR’s 276 thru 283.)
Reference Libraries
December 11, 2015
INHIBITORY EFFECTS OF Á-ARBUTIN ON MELANIN SYNTHESIS IN CULTURED HUMAN MELANOMA CELLS AND A THREE-DIMENSIONAL HUMAN SKIN MODEL.
We studied the inhibitory effects of 4-hydroxyphenyl á-glucopyranoside (á-arbutin) on melanogenesis in cultured human melanoma cells, HMV-II, and in a three-dimensional cultured human skin model. á-Arbutin showed no inhibitory effect on HMV-II cell growth at a concentration below 1.0 mM.... Read More
December 11, 2015
INITIAL IN VITRO SCREENING APPROACH TO INVESTIGATE THE POTENTIAL HEALTH AND ENVIRONMENTAL HAZARDS OF ENVIROX™ – A NANOPARTICULATE CERIUM OXIDE DIESEL FUEL ADDITIVE.
This study by scientists at Oxonica, Product Assessment & Regulatory Compliance, and SafePharm Laboratories Ltd. demonstrated that MatTek’s EpiDerm in vitro tissue model system can be used to determine the skin irritation potential of formulations containing nanoparticles. Nanotechnology is the... Read More
December 11, 2015
PRESENCE OF HYDROCORTISONE DRAMATICALLY AFFECTS CYTOKINE PRODUCTION FOLLOWING UV IRRADIATION IN 3-DIMENSIONAL SKIN MODEL EPIDERM.
Dating back to work originally done by Rheinwald and Green, hydrocortisone (HC) is commonly used in culture media for epithelial cells, especially keratinocytes. In the culture of EpiDerm™, a highly differentiated, three-dimensional model of the human epidermis, this additive is... Read More
December 11, 2015
THE USE OF MATTEK EPIDERMAL EQUIVALENTS FOR PREDICTION OF IRRITATION POTENTIAL.
The need exists for a rapid, accurate in vitro screening protocol, predictive for human skin irritation in response to topically applied products. The EPI-100, EpiDerm™ Human Skin Model System produced by MatTek Corp. (Ashland, MA) is being investigated for this... Read More
