Reference Libraries

Human skin equivalent cultures are being investigated as a pre-clinical skin irritation screen to aid in the design of safe and efficient human studies. Our approach has been to directly compare in vitro to in vivo human skin responses using... Read More

Living, three-dimensional human skin substrates were used to assess the relative skin irritation potential of selected chemicals and prototype shampoo formulations. Scientists at Clairol Inc. and Thomas Stephens Associates exposed two full-thickness skin equivalent models (EpiDerm™ from MatTek Corp. and... Read More

The in vitro evaluation of the dermal irritation potential of volatile or water insoluble petroleum products has generally proved difficult. Scientists at ARCO and Microbiological Associates utilized three human skin constructs (Living Skin Equivalent [LSE], Organogenesis, Inc., Cambridge, MA; Skin2... Read More

The need exists for a rapid, accurate in vitro screening protocol, predictive for human skin irritation in response to topically applied products. The EPI-100, EpiDerm™ Human Skin Model System produced by MatTek Corp. (Ashland, MA) is being investigated for this... Read More

Several in vitro methods for their ability to replicate in vivo effects of selected alpha hydroxy acids and amides on the epidermis and dermis have been investigated. Cytotoxicity, prostaglandin release, morphology and histology on single cells and on tissue models... Read More