Reference Libraries

The in vitro evaluation of the dermal irritation potential of volatile or water insoluble petroleum products has generally proved difficult. Scientists at ARCO and Microbiological Associates utilized three human skin constructs (Living Skin Equivalent [LSE], Organogenesis, Inc., Cambridge, MA; Skin2... Read More

Living, three-dimensional human skin substrates were used to assess the relative skin irritation potential of selected chemicals and prototype shampoo formulations. Scientists at Clairol Inc. and Thomas Stephens Associates exposed two full-thickness skin equivalent models (EpiDerm™ from MatTek Corp. and... Read More

Understanding predictive in vitro testing of topically applied materials is especially important to the pharmacologist who works with the skin since this technology is applied for basic research and product development. This exhibit presents information and data on traditional and... Read More

EpiDerm™ is a model of the human epidermis grown from normal human epidermal keratinocytes (foreskin-derived) seeded onto Millicell® CM (Millipore Corp., Bedford, MA) cell culture inserts. The inserts are placed at the air/culture medium interface allowing the cells to differentiate... Read More

Scientists at Procter & Gamble Co. previously reported the development of a battery of endpoints in human skin cultures that correlate with human skin irritation responses to selected prototype surfactants. The purpose of the present study was to directly compare... Read More