Reference Libraries

December 11, 2015

INTRA- AND INTERLABORATORY REPRODUCIBILITY (ET-50) OF EPIDERM, AN IN VITRO MODEL FOR DERMAL IRRITANCY TESTING.

An in vitro model of the human epidermis, EpiDerm™, cultured from normal human epidermal keratinocytes (NHEK), was introduced by MatTek Corporation in April 1993. Using highly controlled tissue culture techniques, weekly batches of EpiDerm are produced for dermal irritancy testing,... Read More

December 11, 2015

DEVELOPMENT OF IN VITRO METHODS FOR EVALUATING THE EPIDERMAL AND DERMAL EFFECTS OF ALPHA HYDROXY AND AMIDES.

Several in vitro methods for their ability to replicate in vivo effects of selected alpha hydroxy acids and amides on the epidermis and dermis have been investigated. Cytotoxicity, prostaglandin release, morphology and histology on single cells and on tissue models... Read More

December 11, 2015

NEW EPIDERMAL MODEL FOR DERMAL IRRITANCY TESTING.

An interlaboratory comparison of EpiDerm™, a new model of human epidermis, was conducted using a range of anionic and non-ionic surfactants and surfactant-containing final formulations. The toxicity of the materials was estimated by MTT conversion, using both concentration (EC-50) and... Read More

December 11, 2015

DESIGN PRINCIPLES OF CHEMICAL PENETRATION ENHANCERS FOR TRANSDERMAL DRUG DELIVERY.

This study by researchers at the University of California at Santa Barbara demonstrated how MatTek’s EpiDerm human skin tissue equivalent can be used to measure the irritation potential of chemical penetration enhancers (CPEs) present in a large number of transdermal,... Read More

December 11, 2015

LIPID AND ULTRASTRUCTURAL CHARACTERIZATION OF A NEW EPIDERMAL MODEL SHOWS GOOD CORRESPONDENCE TO NORMAL HUMAN EPIDERMIS.

A model of the human epidermis, EpiDerm, based on neonatal foreskin-derived normal human epidermal keratinocytes (NHEK), has recently been characterized by scientists at the University of Iowa College of Dentistry in terms of stratum corneum (SC) lipids and ultrastructure. Cultured... Read More

Reference Libraries

INTRA- AND INTERLABORATORY REPRODUCIBILITY (ET-50) OF EPIDERM, AN IN VITRO MODEL FOR DERMAL IRRITANCY TESTING.

DEVELOPMENT OF IN VITRO METHODS FOR EVALUATING THE EPIDERMAL AND DERMAL EFFECTS OF ALPHA HYDROXY AND AMIDES.

NEW EPIDERMAL MODEL FOR DERMAL IRRITANCY TESTING.

DESIGN PRINCIPLES OF CHEMICAL PENETRATION ENHANCERS FOR TRANSDERMAL DRUG DELIVERY.

LIPID AND ULTRASTRUCTURAL CHARACTERIZATION OF A NEW EPIDERMAL MODEL SHOWS GOOD CORRESPONDENCE TO NORMAL HUMAN EPIDERMIS.

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