Reference Libraries

December 11, 2015

LIPID AND ULTRASTRUCTURAL CHARACTERIZATION OF A NEW EPIDERMAL MODEL SHOWS GOOD CORRESPONDENCE TO NORMAL HUMAN EPIDERMIS.

A model of the human epidermis, EpiDerm, based on neonatal foreskin-derived normal human epidermal keratinocytes (NHEK), has recently been characterized by scientists at the University of Iowa College of Dentistry in terms of stratum corneum (SC) lipids and ultrastructure. Cultured... Read More

December 11, 2015

PERMEABILITY AND CYTOTOXICITY OF MACROMOLECULE FROM NASAL FORMULATION USING EPIAIRWAY TISSUE MODEL.

Hydrophilic macromolecules such as proteins and peptides are poorly absorbed through the nasal mucosa. Nastech Pharmaceuticals has utilized a variety of techniques to improve the nasal absorption of macromolecules with emphasize on achieving safety as well as therapeutic efficacy. EpiAirway,... Read More

December 11, 2015

THE USE OF MATTEK EPIDERMAL EQUIVALENTS FOR PREDICTION OF IRRITATION POTENTIAL.

The need exists for a rapid, accurate in vitro screening protocol, predictive for human skin irritation in response to topically applied products. The EPI-100, EpiDerm™ Human Skin Model System produced by MatTek Corp. (Ashland, MA) is being investigated for this... Read More

December 11, 2015

EVALUATION OF THE USEFULNESS OF 3-D MODELS OF RECONSTITUTED HUMAN SKIN AND EPIDERMIS IN APPLICATIONS OF REGULATORY SKIN TOXICOLOGY: PREVALIDATION, VALIDATION, CATCH-UP VALIDATION, AND REGULATORY ACCEPTANCE.

In 1991 we evaluated a model of full human skin (Skin2, ATS, La Jolla) for phototoxicity testing. The test developed showed promising results as an adjunct to a test performed with Balb/c 3T3 cells. While it detected acute phototoxins correctly,... Read More

December 11, 2015

EVALUATION OF TWO IN VITRO HUMAN SKIN EQUIVALENTS (THE EPIDERM AND SKIN² MODEL ZK1300) FOR ASSESSING THE SKIN IRRITATION POTENTIAL OF PERSONAL CARE PRODUCTS AND CHEMICALS.

Living, three-dimensional human skin substrates were used to assess the relative skin irritation potential of selected chemicals and prototype shampoo formulations. Scientists at Clairol Inc. and Thomas Stephens Associates exposed two full-thickness skin equivalent models (EpiDerm™ from MatTek Corp. and... Read More

Reference Libraries

LIPID AND ULTRASTRUCTURAL CHARACTERIZATION OF A NEW EPIDERMAL MODEL SHOWS GOOD CORRESPONDENCE TO NORMAL HUMAN EPIDERMIS.

PERMEABILITY AND CYTOTOXICITY OF MACROMOLECULE FROM NASAL FORMULATION USING EPIAIRWAY TISSUE MODEL.

THE USE OF MATTEK EPIDERMAL EQUIVALENTS FOR PREDICTION OF IRRITATION POTENTIAL.

EVALUATION OF THE USEFULNESS OF 3-D MODELS OF RECONSTITUTED HUMAN SKIN AND EPIDERMIS IN APPLICATIONS OF REGULATORY SKIN TOXICOLOGY: PREVALIDATION, VALIDATION, CATCH-UP VALIDATION, AND REGULATORY ACCEPTANCE.

EVALUATION OF TWO IN VITRO HUMAN SKIN EQUIVALENTS (THE EPIDERM AND SKIN² MODEL ZK1300) FOR ASSESSING THE SKIN IRRITATION POTENTIAL OF PERSONAL CARE PRODUCTS AND CHEMICALS.

Get the latest

EVALUATION OF TWO IN VITRO HUMAN SKIN EQUIVALENTS (THE EPIDERM AND SKIN² MODEL ZK1300) FOR ASSESSING THE SKIN IRRITATION POTENTIAL OF PERSONAL CARE PRODUCTS AND CHEMICALS.