Reference Libraries

December 11, 2015

LIPID CHARACTERIZATION OF A NEW EPIDERMAL MODEL FOR SKIN IRRITANCY AND PENETRATION STUDIES.

A model of human epidermis, EpiDerm™, based on neonatal, foreskin-derived normal human epidermal keratinocytes (NHEK) has recently been characterized by scientists at the University of Iowa College of Dentistry in terms of stratum corneum lipids, ultrastructure, and barrier properties. Cultured... Read More

December 11, 2015

INTRA- AND INTERLABORATORY REPRODUCIBILITY (ET-50) OF EPIDERM, AN IN VITRO MODEL FOR DERMAL IRRITANCY TESTING.

An in vitro model of the human epidermis, EpiDerm™, cultured from normal human epidermal keratinocytes (NHEK), was introduced by MatTek Corporation in April 1993. Using highly controlled tissue culture techniques, weekly batches of EpiDerm are produced for dermal irritancy testing,... Read More

December 11, 2015

EVALUATION OF EPIDERM FULL THICKNESS-300 (EFT-300) AS AN IN VITRO MODEL FOR SKIN IRRITATION.

This study by scientists at the Colleges of Pharmacy at Florida A&M University and Auburn University, and at MatTek Corp. demonstrated that MatTek’s EpiDerm-FT full thickness human skin tissue equivalent is an excellent alternative to the use of animals for... Read More

December 11, 2015

DESIGN PRINCIPLES OF CHEMICAL PENETRATION ENHANCERS FOR TRANSDERMAL DRUG DELIVERY.

This study by researchers at the University of California at Santa Barbara demonstrated how MatTek’s EpiDerm human skin tissue equivalent can be used to measure the irritation potential of chemical penetration enhancers (CPEs) present in a large number of transdermal,... Read More

December 11, 2015

COMPARISONS OF IN VITRO AND IN VIVO SKIN RESPONSES TO SURFACTANTS WITH A RANGE OF IRRITANCY POTENTIAL.

Scientists at Procter & Gamble Co. previously reported the development of a battery of endpoints in human skin cultures that correlate with human skin irritation responses to selected prototype surfactants. The purpose of the present study was to directly compare... Read More

Reference Libraries

LIPID CHARACTERIZATION OF A NEW EPIDERMAL MODEL FOR SKIN IRRITANCY AND PENETRATION STUDIES.

INTRA- AND INTERLABORATORY REPRODUCIBILITY (ET-50) OF EPIDERM, AN IN VITRO MODEL FOR DERMAL IRRITANCY TESTING.

EVALUATION OF EPIDERM FULL THICKNESS-300 (EFT-300) AS AN IN VITRO MODEL FOR SKIN IRRITATION.

DESIGN PRINCIPLES OF CHEMICAL PENETRATION ENHANCERS FOR TRANSDERMAL DRUG DELIVERY.

COMPARISONS OF IN VITRO AND IN VIVO SKIN RESPONSES TO SURFACTANTS WITH A RANGE OF IRRITANCY POTENTIAL.

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