Reference Libraries

December 11, 2015

NEW EPIDERMAL MODEL FOR DERMAL IRRITANCY TESTING.

An interlaboratory comparison of EpiDerm™, a new model of human epidermis, was conducted using a range of anionic and non-ionic surfactants and surfactant-containing final formulations. The toxicity of the materials was estimated by MTT conversion, using both concentration (EC-50) and... Read More

December 11, 2015

LIPID AND ULTRASTRUCTURAL CHARACTERIZATION OF A NEW EPIDERMAL MODEL SHOWS GOOD CORRESPONDENCE TO NORMAL HUMAN EPIDERMIS.

A model of the human epidermis, EpiDerm, based on neonatal foreskin-derived normal human epidermal keratinocytes (NHEK), has recently been characterized by scientists at the University of Iowa College of Dentistry in terms of stratum corneum (SC) lipids and ultrastructure. Cultured... Read More

December 11, 2015

PERMEABILITY AND CYTOTOXICITY OF MACROMOLECULE FROM NASAL FORMULATION USING EPIAIRWAY TISSUE MODEL.

Hydrophilic macromolecules such as proteins and peptides are poorly absorbed through the nasal mucosa. Nastech Pharmaceuticals has utilized a variety of techniques to improve the nasal absorption of macromolecules with emphasize on achieving safety as well as therapeutic efficacy. EpiAirway,... Read More

December 11, 2015

THE USE OF MATTEK EPIDERMAL EQUIVALENTS FOR PREDICTION OF IRRITATION POTENTIAL.

The need exists for a rapid, accurate in vitro screening protocol, predictive for human skin irritation in response to topically applied products. The EPI-100, EpiDerm™ Human Skin Model System produced by MatTek Corp. (Ashland, MA) is being investigated for this... Read More

December 11, 2015

DEVELOPMENT OF IN VITRO METHODS FOR EVALUATING THE EPIDERMAL AND DERMAL EFFECTS OF ALPHA HYDROXY AND AMIDES.

Several in vitro methods for their ability to replicate in vivo effects of selected alpha hydroxy acids and amides on the epidermis and dermis have been investigated. Cytotoxicity, prostaglandin release, morphology and histology on single cells and on tissue models... Read More

Reference Libraries

NEW EPIDERMAL MODEL FOR DERMAL IRRITANCY TESTING.

LIPID AND ULTRASTRUCTURAL CHARACTERIZATION OF A NEW EPIDERMAL MODEL SHOWS GOOD CORRESPONDENCE TO NORMAL HUMAN EPIDERMIS.

PERMEABILITY AND CYTOTOXICITY OF MACROMOLECULE FROM NASAL FORMULATION USING EPIAIRWAY TISSUE MODEL.

THE USE OF MATTEK EPIDERMAL EQUIVALENTS FOR PREDICTION OF IRRITATION POTENTIAL.

DEVELOPMENT OF IN VITRO METHODS FOR EVALUATING THE EPIDERMAL AND DERMAL EFFECTS OF ALPHA HYDROXY AND AMIDES.

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