Reference Libraries

December 11, 2015

PERMEABILITY AND CYTOTOXICITY OF MACROMOLECULE FROM NASAL FORMULATION USING EPIAIRWAY TISSUE MODEL.

Hydrophilic macromolecules such as proteins and peptides are poorly absorbed through the nasal mucosa. Nastech Pharmaceuticals has utilized a variety of techniques to improve the nasal absorption of macromolecules with emphasize on achieving safety as well as therapeutic efficacy. EpiAirway,... Read More

December 11, 2015

LIPID AND ULTRASTRUCTURAL CHARACTERIZATION OF A NEW EPIDERMAL MODEL SHOWS GOOD CORRESPONDENCE TO NORMAL HUMAN EPIDERMIS.

A model of the human epidermis, EpiDerm, based on neonatal foreskin-derived normal human epidermal keratinocytes (NHEK), has recently been characterized by scientists at the University of Iowa College of Dentistry in terms of stratum corneum (SC) lipids and ultrastructure. Cultured... Read More

December 11, 2015

EVALUATION OF THE USEFULNESS OF 3-D MODELS OF RECONSTITUTED HUMAN SKIN AND EPIDERMIS IN APPLICATIONS OF REGULATORY SKIN TOXICOLOGY: PREVALIDATION, VALIDATION, CATCH-UP VALIDATION, AND REGULATORY ACCEPTANCE.

In 1991 we evaluated a model of full human skin (Skin2, ATS, La Jolla) for phototoxicity testing. The test developed showed promising results as an adjunct to a test performed with Balb/c 3T3 cells. While it detected acute phototoxins correctly,... Read More

December 11, 2015

A REPRODUCIBLE, STRUCTURALLY APPROPRIATE SKIN MODEL FOR DERMAL IRRITANCY AND EFFICACY TESTING.

The ability to determine, in vitro, the efficacy and irritancy of materials contacting the skin critically depends on the accuracy of the skin model in emulating native epidermis’ structure and biochemistry. In addition, for any toxicology or efficacy model to... Read More

December 11, 2015

BIOCONVERSION OF TOCOPHERYL ACETATE TO TOCOPHEROL IN HUMAN SKIN ORGAN CULTURE MODELS.

There is substantial interest in delivering the antioxidant benefits of vitamin E (tocopherol) to the skin. Since free tocopherol is inherently unstable, it is usually delivered to the skin in the form of tocopheryl acetate. The premise behind this approach... Read More

Reference Libraries

PERMEABILITY AND CYTOTOXICITY OF MACROMOLECULE FROM NASAL FORMULATION USING EPIAIRWAY TISSUE MODEL.

LIPID AND ULTRASTRUCTURAL CHARACTERIZATION OF A NEW EPIDERMAL MODEL SHOWS GOOD CORRESPONDENCE TO NORMAL HUMAN EPIDERMIS.

EVALUATION OF THE USEFULNESS OF 3-D MODELS OF RECONSTITUTED HUMAN SKIN AND EPIDERMIS IN APPLICATIONS OF REGULATORY SKIN TOXICOLOGY: PREVALIDATION, VALIDATION, CATCH-UP VALIDATION, AND REGULATORY ACCEPTANCE.

A REPRODUCIBLE, STRUCTURALLY APPROPRIATE SKIN MODEL FOR DERMAL IRRITANCY AND EFFICACY TESTING.

BIOCONVERSION OF TOCOPHERYL ACETATE TO TOCOPHEROL IN HUMAN SKIN ORGAN CULTURE MODELS.

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