Reference Libraries

Scientists at Procter & Gamble Co. previously reported the development of a battery of endpoints in human skin cultures that correlate with human skin irritation responses to selected prototype surfactants. The purpose of the present study was to directly compare... Read More

EpiDerm™ is a model of the human epidermis grown from normal human epidermal keratinocytes (foreskin-derived) seeded onto Millicell® CM (Millipore Corp., Bedford, MA) cell culture inserts. The inserts are placed at the air/culture medium interface allowing the cells to differentiate... Read More

Several in vitro methods for their ability to replicate in vivo effects of selected alpha hydroxy acids and amides on the epidermis and dermis have been investigated. Cytotoxicity, prostaglandin release, morphology and histology on single cells and on tissue models... Read More

An interlaboratory comparison of EpiDerm™, a new model of human epidermis, was conducted using a range of anionic and non-ionic surfactants and surfactant-containing final formulations. The toxicity of the materials was estimated by MTT conversion, using both concentration (EC-50) and... Read More