Reference Libraries

There is a need to investigate the mechanistic basis of the human skin irritation response if relevant in vitro test systems for the predictive identification of skin irritation are to be developed. The aim of this work was to identify... Read More

Scientists at Johnson & Johnson Consumer Products and Neutrogena Corp. previously evaluated the measurement of viability and cytokine release from skin equivalents for predicting the skin irritation potential of topically applied surfactants, and demonstrated that IL-1a and interleukin-1 receptor antagonist... Read More

The goal of this study by researchers at Cosmital SA (Wella AG) and L’Oreal (Life Sciences Research, Centre) was to examine the concordance between human in vivo and in vitro skin irritation classifications of cosmetic products and to evaluate the... Read More

Reconstructed human skin equivalents are currently being investigated as in vitro models for the prediction of human skin toxicity and irritation responses. Three different industrial reconstructed skin models (EpiDerm, Episkin and SkinEthic) and one in-house equivalent were characterized and compared... Read More

Analysis of epidermal proteins from irritant-treated in vitro epidermal models by proteomics is a promising approach to detect new markers of human skin irritation. These data provide a more comprehensive understanding of the mechanisms involved in the skin irritation response.... Read More