Reference Libraries

Understanding the mechanistic basis of the human skin irritation response is key to the development of relevant in vitro test systems for the predictive identification of skin irritation hazards. Recent progress in the development of proteomic and microarray technologies means... Read More

Human skin equivalent cultures were investigated as possible pre-clinical skin irritation screens to aid safety assessments for chemicals and product formulations, and to facilitate design of safe and efficient human studies. In vitro responses in human skin equivalent cultures were... Read More

The goal of this study by researchers at Cosmital SA (Wella AG) and L’Oreal (Life Sciences Research, Centre) was to examine the concordance between human in vivo and in vitro skin irritation classifications of cosmetic products and to evaluate the... Read More

Over the years a number of methods have been developed to assess the potential contact irritancy of cosmetic-related surfactants. These methods include in vitro exposure using skin equivalent cultures, proteins, enzymes, etc. These methods are exaggerated in so far as... Read More