Reference Libraries

Over the years a number of methods have been developed to assess the potential contact irritancy of cosmetic-related surfactants. These methods include in vitro exposure using skin equivalent cultures, proteins, enzymes, etc. These methods are exaggerated in so far as... Read More

Human skin equivalent cultures were investigated as possible pre-clinical skin irritation screens to aid safety assessments for chemicals and product formulations, and to facilitate design of safe and efficient human studies. In vitro responses in human skin equivalent cultures were... Read More

The development of an in vitro method for testing unknown anti-irritant ingredients can provide preliminary estimate of material safety and it is fast and economical before testing on humans. We utilized the MatTek EpiDerm skin model and a primary culture... Read More

The goal of this study by researchers at Cosmital SA (Wella AG) and L’Oreal (Life Sciences Research, Centre) was to examine the concordance between human in vivo and in vitro skin irritation classifications of cosmetic products and to evaluate the... Read More

EpiDerm™ is a commercially available human skin model consisting of normal human-derived epidermal keratinocytes (NHEK), which have been cultured to form a multilayered, highly differentiated model of the human epidermis. We evaluated this model as an alternative to the primary... Read More