Reference Libraries

Analysis of epidermal proteins from irritant-treated in vitro epidermal models by proteomics is a promising approach to detect new markers of human skin irritation. These data provide a more comprehensive understanding of the mechanisms involved in the skin irritation response.... Read More

There is a need to investigate the mechanistic basis of the human skin irritation response if relevant in vitro test systems for the predictive identification of skin irritation are to be developed. The aim of this work was to identify... Read More

Simple in vitro cell culture methods are often inappropriate for investigating the cytotoxicity of high concentration test substances. The relevance of these assays for assessing skin irritation potential substances such as surfactants or surfactant mixtures, where the toxicity of the... Read More

Human skin equivalent cultures were investigated as possible pre-clinical skin irritation screens to aid safety assessments for chemicals and product formulations, and to facilitate design of safe and efficient human studies. In vitro responses in human skin equivalent cultures were... Read More