Reference Libraries

The development of an in vitro method for testing unknown anti-irritant ingredients can provide preliminary estimate of material safety and it is fast and economical before testing on humans. We utilized the MatTek EpiDerm skin model and a primary culture... Read More

Scientists at Johnson & Johnson Consumer Products and Neutrogena Corp. previously evaluated the measurement of viability and cytokine release from skin equivalents for predicting the skin irritation potential of topically applied surfactants, and demonstrated that IL-1a and interleukin-1 receptor antagonist... Read More

A number of diverse in vitro model systems have been employed for the prediction of irritation potential of test articles. Monolayer systems have proven to be useful for preliminary screening but are not always capable of distinguishing mild effects or... Read More

Advances in techniques for culturing human skin cells have led to the development of reconstructed human skin equivalents that closely resemble native human skin. These in vitro models offer a variety of approaches to investigate wound healing, skin ageing, pigmentation,... Read More

Understanding the mechanistic basis of the human skin irritation response is key to the development of relevant in vitro test systems for the predictive identification of skin irritation hazards. Recent progress in the development of proteomic and microarray technologies means... Read More