Reference Libraries

The ability to determine, in vitro, the efficacy and irritancy of materials contacting the skin critically depends on the accuracy of the skin model in emulating native epidermis’ structure and biochemistry. In addition, for any toxicology or efficacy model to... Read More

A number of diverse in vitro model systems have been employed for the prediction of irritation potential of test articles. Monolayer systems have proven to be useful for preliminary screening but are not always capable of distinguishing mild effects or... Read More

Over the years a number of methods have been developed to assess the potential contact irritancy of cosmetic-related surfactants. These methods include in vitro exposure using skin equivalent cultures, proteins, enzymes, etc. These methods are exaggerated in so far as... Read More

Purpose: The aim of this study was to determine if the EpiDerm™ reconstructed human skin model (MatTek Corp.) could be an acceptable alternative to the ISO 10993-required rabbit skin irritation test for assessing medical device biocompatibility. Eleven medical device polymers were... Read More