Reference Libraries

August 23, 2024

In Vitro Irritation Assay and Regulatory Acceptance Two Years after ISO 10993-23:2021 Release

Medical device biological safety testing is transitioning away from the use of animals to more technologically advanced and reliable in vitro alternative methods. The irritation potential of medical devices has historically been evaluated by rabbit testing; however, ISO 10993-23:2021 offers... Read More

August 23, 2024

Optimization and Characterization of Novel ALCAM-Targeting Antibody Fragments for Transepithelial Delivery

Activated leukocyte cell adhesion molecule (ALCAM) is a cell adhesion molecule that supports T cell activation, leukocyte migration, and (lymph)angiogenesis and has been shown to contribute to the pathology of various immune-mediated disorders, including asthma and corneal graft rejection. In... Read More

August 23, 2024

Surfactant Protein D Reverses the Gene Signature of Transepithelial HIV-1 Passage and Restricts the Viral Transfer Across the Vaginal Barrier

Effective prophylactic strategy against the current epidemic of sexually transmitted HIV-1 infection requires understanding of the innate gatekeeping mechanisms at the genital mucosa. Surfactant protein D (SP-D), a member of the collectin family of proteins naturally present in the vaginal... Read More

August 23, 2024

Evaluation of in vitro rat and human airway epithelial models for acute inhalation toxicity testing

In vivo models (mostly rodents) are currently accepted by regulatory authorities for assessing acute inhalation toxicity. Considerable efforts have been made in recent years to evaluate in vitro human airway epithelial models (HAEM) as replacements for in vivo testing. In... Read More

August 22, 2024

Targeting Multiple Hallmarks of Skin Aging: Preclinical and Clinical Efficacy of a Novel Growth Factor-Based Skin Care Serum

The aging process involves numerous biological mechanisms that have been characterized and proposed as the ‘‘hallmarks of aging.’’ Targeting the processes and pathways related to these hallmarks of aging that cause and promote skin aging could provide anti-aging benefits. A... Read More

Reference Libraries

In Vitro Irritation Assay and Regulatory Acceptance Two Years after ISO 10993-23:2021 Release

Optimization and Characterization of Novel ALCAM-Targeting Antibody Fragments for Transepithelial Delivery

Surfactant Protein D Reverses the Gene Signature of Transepithelial HIV-1 Passage and Restricts the Viral Transfer Across the Vaginal Barrier

Evaluation of in vitro rat and human airway epithelial models for acute inhalation toxicity testing

Targeting Multiple Hallmarks of Skin Aging: Preclinical and Clinical Efficacy of a Novel Growth Factor-Based Skin Care Serum

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