Reference Libraries

In accordance with ISO 10993, the rabbit skin irritation test is used to assess medical device biocompatibility, however, this method is time-consuming and expensive.  Our study’s goal was to determine if the EpiDerm™ reconstructed human skin model (MatTek Corp.) could... Read More

Some of the challenges in applying high throughput experimentation (HTE) to materials in contact with natural media or tissues are outlined, with an emphasis on soft materials applied to biological surfaces, such as skin. We overview approaches to soft materials... Read More

In autumn 2007, an international validation study was performed to evaluate the reproducibility and confirm the predictive ability of the EpiDerm Skin Irritation Test (SIT) method (1, 2). In November 2008, ECVAM endorsed the EpiDerm SIT as a full replacement... Read More

Classification and labeling of products with extreme pH values (62 or P11.5) is addressed in chemicals legislation. Following determination of pH and alkaline/acid reserve, additional in vitro tests are needed, especially to substantiate results less than corrosive. However, only limited... Read More