Reference Libraries

A number of diverse in vitro model systems have been employed for the prediction of irritation potential of test articles. Monolayer systems have proven to be useful for preliminary screening but are not always capable of distinguishing mild effects or... Read More

Over the years a number of methods have been developed to assess the potential contact irritancy of cosmetic-related surfactants. These methods include in vitro exposure using skin equivalent cultures, proteins, enzymes, etc. These methods are exaggerated in so far as... Read More

This paper details the effort by MatTek scientists to increase the sensitivity of the Skin Irritation Test (SIT) method based on MatTek’s EpiDerm in vitro 3-D human skin tissue equivalent. This effort led to the EpiDerm SIT method being validated... Read More

Determination of skin irritation potential is an international regulatory requirement to ensure safe handling, packaging, labeling and transport of chemicals and evaluation of cosmetics and household products. Recent REACH legislation and a ban on animal testing for cosmetics have heightened... Read More

Although ortho-phthalaldehyde (OPA) has been suggested as an alternative to glutaraldehyde for the sterilization and disinfection of hospital equipment, the toxicity has not been thoroughly investigated. The purpose of these studies was to evaluate the irritancy and sensitization potential of... Read More