Reference Libraries

This multi-center validation study performed by scientists at BfR (ZEBET), BASF SE, the Institute for In Vitro Sciences, Inc., the Centre for Alternative and Complementary Methods to Animal Testing (zet–LSL) and MatTek Corp. demonstrated that the modified Skin Irritation Test... Read More

This study by scientists at MatTek Corp. demonstrated that a modification of the common Skin Irritation protocol that extended the exposure time from 15 minutes to 60 minutes for MatTek’s EpiDerm in vitro human skin tissue model produced a significant... Read More

Arachidonic acid (AA), a precursor of pro-inflammatory mediators, and its glycerin ester, glyceryl arachidonate (GA), are reportedly used in cosmetic products. In vitro skin penetration of AA and GA and GA’s ester hydrolysis was determined in flow-through diffusion cells. AA... Read More

This study by researchers at Unilever’s Safety and Environmental Assurance Centre (SEAC) demonstrated how MatTek’s EpiDerm in vitro human skin tissue equivalent was used to identify a number of proteins that could be used as general markers for skin irritation.... Read More

This study by scientists at Procter & Gamble demonstrated the ability to use MatTek’s EpiDerm in vitro human tissue equivalent as a preclinical test to confirm the mildness of prototype liquid antiperspirant formulations prior to beginning human clinical evaluations. Topical... Read More