Reference Libraries

Arachidonic acid (AA), a precursor of pro-inflammatory mediators, and its glycerin ester, glyceryl arachidonate (GA), are reportedly used in cosmetic products. In vitro skin penetration of AA and GA and GA’s ester hydrolysis was determined in flow-through diffusion cells. AA... Read More

This study by scientists at MatTek Corp. demonstrated that a modification of the common Skin Irritation protocol that extended the exposure time from 15 minutes to 60 minutes for MatTek’s EpiDerm in vitro human skin tissue model produced a significant... Read More

This multi-center validation study performed by scientists at BfR (ZEBET), BASF SE, the Institute for In Vitro Sciences, Inc., the Centre for Alternative and Complementary Methods to Animal Testing (zet–LSL) and MatTek Corp. demonstrated that the modified Skin Irritation Test... Read More

This peer-reviewed, PubMed-indexed VIDEO technical article produced by scientists at MatTek Corp. and published in JoVE (Journal of Visualized Experiments) provides detailed instructions on how to perform the ECVAM-Validated EpiDerm Skin Irritation Test (SIT) Method, a stand-alone full replacement for... Read More

Purpose: The aim of this study was to determine if the EpiDerm™ reconstructed human skin model (MatTek Corp.) could be an acceptable alternative to the ISO 10993-required rabbit skin irritation test for assessing medical device biocompatibility. Eleven medical device polymers were... Read More