Reference Libraries

December 11, 2015

PROTEOMIC ANALYSIS OF THE RESPONSE OF EPIDERM™ CULTURES TO SODIUM LAURYL SULPHATE.

This study by researchers at Unilever’s Safety and Environmental Assurance Centre (SEAC) demonstrated how MatTek’s EpiDerm in vitro human skin tissue equivalent was used to identify a number of proteins that could be used as general markers for skin irritation.... Read More

December 11, 2015

MEETING REQUIREMENTS OF OECD TG 404 FOR IN VITRO SKIN IRRITATION TESTING: REPRODUCIBILITY OF EPIDERM SKIN IRRITATION TEST (EPIDERM-SIT) FOLLOWING ECVAM VALIDATION AND ACCEPTANCE AS A FULL REPLACEMENT METHOD.

In autumn 2007, an international validation study was performed to evaluate the reproducibility and confirm the predictive ability of the EpiDerm Skin Irritation Test (SIT) method (1, 2). In November 2008, ECVAM endorsed the EpiDerm SIT as a full replacement... Read More

December 11, 2015

SCREENING SOFT MATERIALS FOR THEIR EFFECT ON SKIN BARRIER FUNCTION BY HIGH THROUGHPUT EXPERIMENTATION.

Some of the challenges in applying high throughput experimentation (HTE) to materials in contact with natural media or tissues are outlined, with an emphasis on soft materials applied to biological surfaces, such as skin. We overview approaches to soft materials... Read More

December 11, 2015

THE ECVAM PREVALIDATION STUDY ON THE USE OF EPIDERM FOR SKIN CORROSIVITY TESTING.

In 1996 and 1997, ECVAM supported a formal validation study on in vitro methods for predicting skin corrosivity. Two of the in vitro tests included in the study employed human skin models, the Skin ZK1350 and EPISKIN™ models. In the... Read More

December 11, 2015

DEVELOPMENT OF AN IN VITRO METHOD FOR SKIN CORROSION TESTING.

Scientists from The Procter and Gamble Company investigated the feasibility of an in-vitro skin corrosion test method using commercially available human skin cultures. Skin2 from Advanced Tissue Sciences and EpiDerm from MatTek were evaluated for their responses to 24 corrosive... Read More

Reference Libraries

PROTEOMIC ANALYSIS OF THE RESPONSE OF EPIDERM™ CULTURES TO SODIUM LAURYL SULPHATE.

MEETING REQUIREMENTS OF OECD TG 404 FOR IN VITRO SKIN IRRITATION TESTING: REPRODUCIBILITY OF EPIDERM SKIN IRRITATION TEST (EPIDERM-SIT) FOLLOWING ECVAM VALIDATION AND ACCEPTANCE AS A FULL REPLACEMENT METHOD.

SCREENING SOFT MATERIALS FOR THEIR EFFECT ON SKIN BARRIER FUNCTION BY HIGH THROUGHPUT EXPERIMENTATION.

THE ECVAM PREVALIDATION STUDY ON THE USE OF EPIDERM FOR SKIN CORROSIVITY TESTING.

DEVELOPMENT OF AN IN VITRO METHOD FOR SKIN CORROSION TESTING.

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