Reference Libraries

Some of the challenges in applying high throughput experimentation (HTE) to materials in contact with natural media or tissues are outlined, with an emphasis on soft materials applied to biological surfaces, such as skin. We overview approaches to soft materials... Read More

Classification and labeling of products with extreme pH values (62 or P11.5) is addressed in chemicals legislation. Following determination of pH and alkaline/acid reserve, additional in vitro tests are needed, especially to substantiate results less than corrosive. However, only limited... Read More

Arachidonic acid (AA), a precursor of pro-inflammatory mediators, and its glycerin ester, glyceryl arachidonate (GA), are reportedly used in cosmetic products. In vitro skin penetration of AA and GA and GA’s ester hydrolysis was determined in flow-through diffusion cells. AA... Read More

A major milestone for in vitro skin irritation testing was achieved with the recent release of the Statement on the Validity of In-Vitro Tests for Skin Irritation by the European Centre for the Validation of Alternative Methods (ECVAM) Scientific Advisory... Read More