Reference Libraries

A major milestone for in vitro skin irritation testing was achieved with the recent release of the Statement on the Validity of In-Vitro Tests for Skin Irritation by the European Centre for the Validation of Alternative Methods (ECVAM) Scientific Advisory... Read More

Arachidonic acid (AA), a precursor of pro-inflammatory mediators, and its glycerin ester, glyceryl arachidonate (GA), are reportedly used in cosmetic products. In vitro skin penetration of AA and GA and GA’s ester hydrolysis was determined in flow-through diffusion cells. AA... Read More

Although ortho-phthalaldehyde (OPA) has been suggested as an alternative to glutaraldehyde for the sterilization and disinfection of hospital equipment, the toxicity has not been thoroughly investigated. The purpose of these studies was to evaluate the irritancy and sensitization potential of... Read More

This multi-center validation study performed by scientists at BfR (ZEBET), BASF SE, the Institute for In Vitro Sciences, Inc., the Centre for Alternative and Complementary Methods to Animal Testing (zet–LSL) and MatTek Corp. demonstrated that the modified Skin Irritation Test... Read More

This peer-reviewed, PubMed-indexed VIDEO technical article produced by scientists at MatTek Corp. and published in JoVE (Journal of Visualized Experiments) provides detailed instructions on how to perform the ECVAM-Validated EpiDerm Skin Irritation Test (SIT) Method, a stand-alone full replacement for... Read More