Reference Libraries

December 11, 2015

RETROSPECTIVE ANALYSIS OF THE EPIDERM 3-MINUTE PREDICTION MODEL FOR ASSESSMENT OF GHS SKIN CORROSION PACKING GROUP SUB-CATEGORY 1A.

OECD has adopted several ECVAM-validated reconstructed human skin models (EpiDerm and EPISKIN/SkinEthic) for testing skin corrosion as OECD TG 431(1). However, OECD TG 431 does not satisfy international (GHS) labeling guidelines for transport of dangerous goods. GHS package labeling guidelines... Read More

December 11, 2015

Phenotypic Responses of Differentiated Asthmatic Human Airway Epithelial Cultures to Rhinovirus

Objectives: Human airway epithelial cells are the principal target of human rhinovirus (HRV), a common cold pathogen that triggers the majority of asthma exacerbations. The objectives of this study were 1) to evaluate an in vitro air liquid interface cultured... Read More

December 11, 2015

ADAPTATION OF HUMAN PARAINFLUENZA VIRUS TO AIRWAY EPITHELIUM REVEALS FUSION PROPERTIES REQUIRED FOR GROWTH IN HOST TISSUE.

Paramyxoviruses, a family of RNA enveloped viruses that includes human parainfluenza virus type 3 (HPIV3), cause the majority of childhood croup, bronchiolitis, and pneumonia worldwide. Infection starts with host cell receptor binding and fusion of the viral envelope with the... Read More

December 11, 2015

IN VITRO SKIN CORROSION TEST: LONG TERM REPRODUCIBILITY AND RELIABILITY FOR A REGULATORY ACCEPTED METHOD.

This study by scientists at the Institute for In Vitro Sciences (IIVS) and MatTek Corp. demonstrated the long term reproducibility and reliability of MatTek’s EpiDerm tissue model and the EpiDerm Dermal Corrosion assay protocol, as required by regulators. The EpiDerm... Read More

December 11, 2015

THE SKIN CANCER CHEMOTHERAPEUTIC AGENT INGENOL-3-ANGELATE (PEP005) IS A SUBSTRATE FOR THE EPIDERMAL MULTIDRUG TRANSPORTER (ABCB1) AND TARGETS TUMOR VASCULATURE.

Ingenol-3-angelate (Ing3A), extracted from Euphorbia peplus, is currently in clinical trials for eradicating basal cell carcinoma, actinic keratosis, and squamous cell carcinoma (SCC) in situ by topical application. Although structurally related to phorbol esters and a protein kinase C activator,... Read More

Reference Libraries

RETROSPECTIVE ANALYSIS OF THE EPIDERM 3-MINUTE PREDICTION MODEL FOR ASSESSMENT OF GHS SKIN CORROSION PACKING GROUP SUB-CATEGORY 1A.

Phenotypic Responses of Differentiated Asthmatic Human Airway Epithelial Cultures to Rhinovirus

ADAPTATION OF HUMAN PARAINFLUENZA VIRUS TO AIRWAY EPITHELIUM REVEALS FUSION PROPERTIES REQUIRED FOR GROWTH IN HOST TISSUE.

IN VITRO SKIN CORROSION TEST: LONG TERM REPRODUCIBILITY AND RELIABILITY FOR A REGULATORY ACCEPTED METHOD.

THE SKIN CANCER CHEMOTHERAPEUTIC AGENT INGENOL-3-ANGELATE (PEP005) IS A SUBSTRATE FOR THE EPIDERMAL MULTIDRUG TRANSPORTER (ABCB1) AND TARGETS TUMOR VASCULATURE.

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