This webinar reviews the first phase our New Approach Methodology (NAM) inhalation toxicology test, developed in partnership with Charles River Laboratories. This phase evaluated the acute toxicity of a panel of chemicals with known inhalation risk assessment categories in 2D and 3D human airway models, as well as a 3D rat airway epithelial model. This work is part of a larger program which also includes repeat dose responses, aerosol vs liquid applications, and donor differences, with the eventual goal of generating a prediction model for inhalation risk of aerosol chemicals.
Watch the webinar below
Download the Poster
Presented at the 2025 Society of Toxicology Meeting, this poster details the results of the first phase of this project to implement a NAMs-based inhalation toxicity testing platform at Charles River Laboratories. Download the Poster
Meet Our Panelists:
Dr. Seyoum Ayehunie
Chief Scientific Officer
MatTek Life Sciences
Head of Discovery Toxicology and Pharmacology
Charles River Laboratories
Dr. Mary McElroy is Head of Discovery Toxicology and Pharmacology at Charles River Laboratories, Edinburgh. In this capacity, Mary’s team run in vitro safety assessments studies including lung organotypic cultures for human relevant risk assessment by inhalation route and are co-investigators on an American Chemical Council with MatTek. Prior to Charles River, Mary spent her career performing lung-related cell-biology, pharmacology, and toxicology. Mary has an MSc in Toxicology from University of Surrey, PhD in Human Lung Development from the University of Southampton, post-doctoral research on alveolar epithelial cell biology at University of California San Francisco, Lecturer/Group Leader positions at the Trinity Collage Dublin and University of Edinburgh. Mary is a European Registered Toxicologist and holds an MBA from the Open University. Connect on LinkedIn
